54345-61-8Relevant articles and documents
OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE
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Page/Page column 102, (2013/05/09)
Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
MITOCHONDRIAL INHIBITORS TO TREAT HUMAN DISEASE
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Page/Page column 10-11, (2010/11/04)
The present invention relates to inhibitors of mitochondria-associated, granulocyte- macrophage colony stimulating factor signaling molecule (Magmas), and related compositions and uses thereof.
Design, synthesis of novel peptidomimetic derivatives of 4-HPR for rhabdoid tumors
Das, Bhaskar C.,Smith, Melissa E.,Kalpana, Ganjam V.
scheme or table, p. 4177 - 4180 (2009/05/07)
Rhabdoid tumors (RTs) are an extremely aggressive pediatric malignancy that results from loss of the INI1/hSNF5 tumor suppressor gene. Loss of INI1 results in aberrant expression of Cyclin D1, which supports rhabdoid tumorigenesis and survival. 4-HPR, a s