54345-61-8

Upstream product

• 1197-92-8 1-(2,6,6-trimethyl-cyclohex-1-enyl)-ethanone 
• 75-07-0 acetaldehyde 
• 189633-81-6 2‐iodo‐1,3,3‐trimethylcyclohex‐1‐ene 
• 917-64-6 methyl magnesium iodide 
• 432-25-7 2,6,6-trimethylcyclohex-1-enecarbaldehyde 
• 1892-05-3 2-ethynyl-1,3,3-trimethyl-1-cyclohexene 
• 189633-82-7 2,2,6-trimethyl-cyclohexanone hydrazone 
• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 6627-74-3 (+/-)-α-cyclogeraniol 
• 917-54-4 methyllithium 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 54345-63-0 Acetic acid 1-(2,6,6-trimethyl-cyclohex-1-enyloxy)-ethyl ester 
• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 1197-92-8 1-(2,6,6-trimethyl-cyclohex-1-enyl)-ethanone 
• 75154-28-8 2-Eth-(Z)-ylidene-1-(2-iodo-ethyl)-1,3,3-trimethyl-cyclohexane 
• 75154-30-2 4-[2-Eth-(Z)-ylidene-1,3,3-trimethyl-cyclohexyl]-butyric acid methyl ester 
• 75154-31-3 4-{2-[2-Bromo-eth-(Z)-ylidene]-1,3,3-trimethyl-cyclohexyl}-butyric acid methyl ester 
• 75154-33-5 4-((1R,2S)-2-Hydroxy-1,3,3-trimethyl-2-vinyl-cyclohexyl)-butyric acid methyl ester 
• 75154-29-9 2-{2-[2-Eth-(Z)-ylidene-1,3,3-trimethyl-cyclohexyl]-ethyl}-malonic acid dimethyl ester 
• 1159030-75-7 Br^(1-)*C₂₉H₃₄P⁽¹⁺⁾ 
• 1431464-48-0 3-hydroxy-3-phenyl-1-(2,6,6-trimethylcyclohex-1-enyl)propan-1-one 
• 334826-81-2 (E)-3-phenyl-1-(2,6,6-trimethylcyclohex-1-enyl)prop-2-en-1-one 
• 1431464-50-4 3-hydroxy-4-methyl-1-(2,6,6-trimethylcyclohex-1-enyl)pentan-1-one 
• 1431464-56-0 (E)-1-(2,6,6-trimethylcyclohex-1-enyl)pent-2-en-1-one 
• 1431464-65-1 3-hydroxy-4,4-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)pentan-1-one 

Relevant academic research and scientific papers

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Design, synthesis, and biological activity of novel Magmas inhibitors

Magmas (mitochondria associated, granulocyte-macrophage colony stimulating factor signaling molecule), is a highly conserved and essential gene, expressed in all cell types. We designed and synthesized several small molecule Magmas inhibitors (SMMI) and a

MITOCHONDRIAL INHIBITORS TO TREAT HUMAN DISEASE

The present invention relates to inhibitors of mitochondria-associated, granulocyte- macrophage colony stimulating factor signaling molecule (Magmas), and related compositions and uses thereof.

Design and synthesis of (E)-4-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl)benzoic acid

(E)-4-((3-Ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl)benzoic acid, 6, was synthesized in 87% starting from β-cyclocitral. The target compound 6 was synthesized starting from 1 via a Grignard reaction to form alcohol 2. Compound 2 was converted to Wi

Design, synthesis of novel peptidomimetic derivatives of 4-HPR for rhabdoid tumors

Rhabdoid tumors (RTs) are an extremely aggressive pediatric malignancy that results from loss of the INI1/hSNF5 tumor suppressor gene. Loss of INI1 results in aberrant expression of Cyclin D1, which supports rhabdoid tumorigenesis and survival. 4-HPR, a s

Total synthesis of (±)-hedychenone: Trimethyldecalin terpene systems via stepwise allenoate diene cycloaddition

(Diagram presented) The total synthesis of hedychenone 1 is described. The cycloaddition of the hindered diene 2 and the allenecarboxylate 3 has been shown conclusively to proceed via the [2+2] cycloadduct 5 to give a 2:1 mixture of the desired formal Diels-Alder adducts, the exo and endo isomers 4xn and is thus a stepwise [4+2] cycloaddition. The exo isomer 4x was converted in four steps (reduction, oxidation, olefination, and desilylation) into hedychenone 1.

Synthesis of Insert Antifeedants Related to Azadiradione

An efficient synthesis of a model insect antifeedant based on the C, D and E rings of the limonoid azadiradione has been developed. (8 steps 18percent overall yield).The key steps were an electrocyclization induced by acids 4->5 and a dyotropic rearran