1159030-75-7Relevant academic research and scientific papers
Design, synthesis, and biological activity of novel Magmas inhibitors
Jubinsky, Paul T.,Short, Mary K.,Ghanem, Mohmoud,Das, Bhaskar C.
supporting information; experimental part, p. 3479 - 3482 (2011/07/07)
Magmas (mitochondria associated, granulocyte-macrophage colony stimulating factor signaling molecule), is a highly conserved and essential gene, expressed in all cell types. We designed and synthesized several small molecule Magmas inhibitors (SMMI) and a
Design and synthesis of potential new apoptosis agents: hybrid compounds containing perillyl alcohol and new constrained retinoids
Das, Bhaskar C.,Mahalingam, Sakkarapalayam M.,Panda, Lipsa,Wang, Bo,Campbell, Phillp D.,Evans, Todd
scheme or table, p. 1462 - 1466 (2010/04/29)
Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N,N′-dicyclohexyl carbodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.
Design and synthesis of (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2- enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl) ethanol
Das, Bhaskar C.,Mahalingam, Sakkarapalayam M.,Evans, Todd,Kabalka, George W.,Anguiano,Hema
scheme or table, p. 2133 - 2135 (2009/09/05)
A novel strategy for synthesizing (E)-1-((3-ethyl-2,4,4-trimethylcyclohex- 2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1- enyl)ethanol 3 has been developed; the allylic alcohol 3 was treated with PPh3·HBr in methan
