7285-66-7

Basic information

• Product Name: 3-chlorobiphenyl-4-amine
• Synonyms: 3-chlorobiphenyl-4-amine
• CAS NO: 7285-66-7
• Molecular Formula: C₁₂H₁₀ClN
• Molecular Weight: 203.6675
• Mol File: 7285-66-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-chlorobiphenyl-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chlorobiphenyl-4-amine(7285-66-7)
• EPA Substance Registry System: 3-chlorobiphenyl-4-amine(7285-66-7)

Safety Data

• Hazardous Substances Data: 7285-66-7(Hazardous Substances Data)

Usage

General Description

3-Chlorobiphenyl-4-amine, also known as 4-Amino-3-chlorobiphenyl, is a chemical compound with the formula C12H10ClN. It is a derivative of biphenyl and contains a chlorine atom and an amino group attached to the 4th carbon atom of the biphenyl ring. 3-chlorobiphenyl-4-amine is used in the production of various industrial and agricultural chemicals, as a building block in organic synthesis, and as a precursor to pharmaceuticals. It is also used in the synthesis of dyes and pigments. 3-Chlorobiphenyl-4-amine may have potential health hazards and should be handled and disposed of according to proper safety and environmental procedures.

Upstream product

• 91331-24-7 3-chloro-4-nitro-1,1'-biphenyl 
• 146474-28-4 N-Acetyl-3-chloro-4-aminobiphenyl 
• 95745-23-6 triphenyl(3-chloro-4-aminophenyl)methane 
• 7647-01-0 hydrogenchloride 
• 26541-56-0 N-acetoxy-N-acetylaminobiphenyl (AAABP) 
• 6810-26-0 4-hydroxylaminobiphenyl 
• 4075-79-0 4-phenylacetanilide 
• 150786-99-5 N-chloro-4-(acetylamino)biphenyl 
• 825-41-2 3-chloro-4-nitroaniline 
• 71-43-2 benzene 
• 92-67-1 4-phenylalanine 
• 38762-41-3 2-chloro-4-bromoaniline 
• 98-80-6 phenylboronic acid 

Downstream Products

• 98023-62-2 3-Chlor-4-<4-decyloxy-benzylidenamino>-biphenyl 
• 96868-55-2 3-Chlor-4-<4-heptyloxy-benzylidenamino>-biphenyl 
• 96113-63-2 3-Chlor-4-<4-Octyloxy-benzylidenamino>-biphenyl 
• 96275-74-0 3-Chlor-4-<4-nonyloxy-benzylidenamino>-biphenyl 
• 5435-92-7 3-chloro-[1,1'-biphenyl]-4-carbonitrile 
• 1402905-16-1 2,6-diphenylphenanthridine 
• 1402905-47-8 C₂₅H₁₈ClN 
• 5728-40-5 3-chloro-[1,1'-biphenyl]-4-carboxylic acid 
• 126866-35-1 3-bromo-5-chloro-1,1’-biphenyl 
• 112272-83-0 N-(3-chloro-biphenyl-4-yl)-phthalamic acid 

Relevant articles and documents

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives

4,4″-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Plasmodium falciparum, and Leishmania amazonensis. Twenty-three compounds were highly active against T. b. rhodesiense or P. falciparum. Most noteworthy were amidines 1, 10, and 11 with IC50 of 4 nM against T. b. rhodesiense, and dimethyltetrahydropyrimidinyl analogues 4 and 9 with IC50 values of ≤ 3 nM against P. falciparum. Bis-pyridylimidamide derivative 31 was 25 times more potent than benznidazole against T. cruzi and slightly more potent than amphotericin B against L. amazonensis. Terphenyldiamidine 1 and dipyridylbenzene analogues 23 and 25 each cured 4/4 mice infected with T. b. rhodesiense STIB900 with four daily 5 mg/kg intraperitoneal doses, as well as with single doses of ≤10 mg/kg. Derivatives 5 and 28 (prodrugs of 1 and 25) each cured 3/4 mice with four daily 25 mg/kg oral doses.

Photolysis of Tetraarylmethanes and 3-(Triarylmethyl)pyridines

Upon UV irradiation in benzene-methanol (1:2) tetraarylmethanes or 3-(triarylmethyl)pyridines underwent an α,α-elimination of two aryl groups to give biaryls or 3-arylpyridine, and two corresponding carbene intermediates.The latters afforded methyl ethers by O-H insertion to methanol.