54356-29-5

Upstream product

• 60093-15-4 N⁵-phenyl-1,2,4-thiadiazole-3,5-diamine 
• 98-88-4 benzoyl chloride 
• 7788-14-9 5-phenyl-1,2,4-oxadiazol-3-amine 
• 103-72-0 phenyl isothiocyanate 
• 15989-47-6 1-phenyl-3-guanylthiourea 

Downstream Products

• 104424-07-9 N-(2-benzoyl-3-benzoylimino-2,3-dihydro-[1,2,4]thiadiazol-5-yl)-N-phenyl-benzamide 

Relevant academic research and scientific papers

Mononuclear heterocyclic rearrangements. Part 11. Rearrangements of 1,2,4-oxadiazoles, isoxazoles, and 1,2,5-oxadiazoles involving a sulphur atom

The reactions of 3-amino-5-methyl- and 3-amino-5-phenyl-1,2,4-oxadiazoles, 3-amino-5-methylisoxazole, and 3-amino-4-methyl- and 3-amino-4-phenyl-1,2,5- oxadiazoles with phenyl isothiocyanate have been investigated, and the reactivity of phenylthioureido-derivatives (3) of these ring systems towards rearrangement have been studied. The presence of a sulphur atom in the side-chain sequence (1; XYZ = NCS) greatly enhances the reactivity of the systems under consideration towards rearrangement. The tendency of the three heterocycles to rearrange decreases in the order 1,2,4-oxadiazole > isoxazole > 1,2,5-oxadiazole.