54368-61-5

Basic information

• Product Name: ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE
• Synonyms: ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE;2,6-dichloro-5-nitropyrimidine-4-carboxylic acid ethyl ester;2,6-Dichloro-4-(ethoxycarbonyl)-5-nitropyrimidine
• CAS NO: 54368-61-5
• Molecular Formula: C₇H₅Cl₂N₃O₄
• Molecular Weight: 266.04
• Product Categories: Pyrimidine series
• Mol File: 54368-61-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 36-38°C
• Boiling Point: 391.4 °C at 760 mmHg
• Flash Point: 190.5 °C
• Appearance: /
• Density: 1.602
• Vapor Pressure: 2.47E-06mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -9.02±0.39(Predicted)
• CAS DataBase Reference: ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE(54368-61-5)
• EPA Substance Registry System: ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE(54368-61-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 54368-61-5(Hazardous Substances Data)

Usage

Uses

Ethyl 2,6-Dichloro-5-nitropyrimidine-4-carboxylate is a useful chemical compound for preparation of pyrimidinediamines as IgE and/or IgG receptor modulators.

InChI:InChI=1/C7H5Cl2N3O4/c1-2-16-6(13)3-4(12(14)15)5(8)11-7(9)10-3/h2H2,1H3

Upstream product

• 65-86-1 orotic acid 
• 17687-24-0 5-nitroorotic acid 
• 16632-21-6 5-nitro-6-methyluracil 
• 626-48-2 6-Methyluracil 
• 52047-16-2 ethyl 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate 

Downstream Products

• 189747-34-0 2,8-dichloropyrimido(5,4-d)pyrimidine 
• 189747-29-3 5-amino-2-chloropyrimidine-4-carboxamide 

Relevant articles and documents

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Method for synthesizing 2-chloro-5-amino-6-pyrimidine ethyl formate

The invention discloses a method for synthesizing 2-chloro-5-amino-6-pyrimidine ethyl formate. The method comprises the following steps: firstly, enabling fuming nitric acid, concentrated sulfuric acid and orotic acid to react so as to obtain nitroorotic acid; further mixing the obtained nitroorotic acid with ethanol, and adding dropwise the concentrated sulfuric acid at room temperature so as toobtain nitroorotic acid ethyl ester; enabling the nitroorotic acid ethyl ester to react with phosphorus oxychloride and an organic alkali so as to obtain 2,4-dichloro-5-nitro-6-pyrimidine ethyl formate; and finally mixing the 2,4-dichloro-5-nitro-6-pyrimidine ethyl formate with palladium carbon and magnesium oxide, putting the mixture into tetrahydrofuran, and performing a reaction, so as to obtain a final product. By adopting the method, the orotic acid in the market is adopted as a raw material, and the 2-chloro-5-amino-6-pyrimidine ethyl formate is prepared through reactions of nitration, esterification, chlorination and reduction. The method is convenient in process operation, simple in operation, gentle in reaction and small in pollution, in addition, the prepared pyrimidine is high in yield and purity and small in environment pollution, and the prepared 2-chloro-5-amino-6-pyrimidine ethyl formate prepared by using the method can be applied to large-scale production.

New Derivatives of 5-Nitroorotic acid, and the Synthesis of 4-Ethoxycarbonyl-2-N-methylanilino-5,6,7,8-tetrahydropteridine

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