52047-16-2

Usage

Uses

Used in Academic and Industrial Research:
Ethyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate is used as a reagent or intermediate in chemical synthesis processes for its unique structural features and properties. It contributes to the development of new compounds and materials in various fields of research.
Used in Chemical Synthesis:
In the chemical synthesis industry, ethyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate serves as a key intermediate, facilitating the production of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its versatile structure allows for further functionalization and modification, enabling the synthesis of a wide range of target molecules.
Used in Material Science:
Ethyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate can be employed in the development of advanced materials, such as polymers, coatings, and composites, due to its reactive functional groups and compatibility with various other chemical entities. Its incorporation into these materials can impart unique properties and improve performance in specific applications.
Used in Pharmaceutical Development:
As a component of the Pyrimidines and Pyrimidine derivatives family, ethyl 5-nitro-2,6-dioxo-3H-pyrimidine-4-carboxylate holds potential in the pharmaceutical industry. It can be utilized in the design and synthesis of new drug candidates, particularly those targeting various diseases and conditions. Its unique structure and functional groups may contribute to the development of novel therapeutic agents with improved efficacy and selectivity.

InChI:InChI=1/C7H7N3O6/c1-2-16-6(12)3-4(10(14)15)5(11)9-7(13)8-3/h2H2,1H3,(H2,8,9,11,13)

Upstream product

• 64-17-5 ethanol 
• 17687-24-0 5-nitroorotic acid 
• 107-14-2 chloroacetonitrile 
• 65-86-1 orotic acid 
• 16632-21-6 5-nitro-6-methyluracil 
• 626-48-2 6-Methyluracil 

Downstream Products

• 124764-14-3 4-chloro-6-ethoxycarbonyl-2-N-methylanilino-5-nitropyrimidine 
• 54368-61-5 ethyl 2,4-dichloro-5-nitro-6-pyrimidinecarboxylic acid 
• 23000-37-5 2,4,8-Trioxo-hexahydro-pyrimido<5,4-d>pyrimidin 
• 108262-83-5 7-Cyclohexyl-1,7-dihydro-pyrimido[5,4-d]pyrimidine-2,4,8-trione 
• 108262-67-5 7-Benzyl-2,4,8(1H,3H,7H)pyrimido<5,4-d>pyrimidinetrione 
• 108262-71-1 7-Cyclohexylmethyl-1,7-dihydro-pyrimido[5,4-d]pyrimidine-2,4,8-trione 
• 108284-69-1 7-Benzyl-1,3-dimethyl-2,4,8(1H,3H,7H)pyrimido<5,4-d>pyrimidinetrione 
• 108262-72-2 7-(3-Phenyl-propyl)-1,7-dihydro-pyrimido[5,4-d]pyrimidine-2,4,8-trione 
• 108262-75-5 7-(2-Hydroxy-1-hydroxymethyl-2-phenyl-ethyl)-1,7-dihydro-pyrimido[5,4-d]pyrimidine-2,4,8-trione 
• 108262-77-7 7-[2-(3,4-Dimethoxy-phenyl)-ethyl]-1,7-dihydro-pyrimido[5,4-d]pyrimidine-2,4,8-trione 

Relevant academic research and scientific papers

NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds as inhibitors of receptor tyrosine kinases, in particular oncogenic mutants of ErbB-receptors e.g. in the treatment of cancer.

Method for synthesizing 2-chloro-5-amino-6-pyrimidine ethyl formate

The invention discloses a method for synthesizing 2-chloro-5-amino-6-pyrimidine ethyl formate. The method comprises the following steps: firstly, enabling fuming nitric acid, concentrated sulfuric acid and orotic acid to react so as to obtain nitroorotic acid; further mixing the obtained nitroorotic acid with ethanol, and adding dropwise the concentrated sulfuric acid at room temperature so as toobtain nitroorotic acid ethyl ester; enabling the nitroorotic acid ethyl ester to react with phosphorus oxychloride and an organic alkali so as to obtain 2,4-dichloro-5-nitro-6-pyrimidine ethyl formate; and finally mixing the 2,4-dichloro-5-nitro-6-pyrimidine ethyl formate with palladium carbon and magnesium oxide, putting the mixture into tetrahydrofuran, and performing a reaction, so as to obtain a final product. By adopting the method, the orotic acid in the market is adopted as a raw material, and the 2-chloro-5-amino-6-pyrimidine ethyl formate is prepared through reactions of nitration, esterification, chlorination and reduction. The method is convenient in process operation, simple in operation, gentle in reaction and small in pollution, in addition, the prepared pyrimidine is high in yield and purity and small in environment pollution, and the prepared 2-chloro-5-amino-6-pyrimidine ethyl formate prepared by using the method can be applied to large-scale production.