189747-34-0

Basic information

• Product Name: Pyrimido[5,4-d]pyrimidine, 2,8-dichloro-
• Synonyms: Pyrimido[5,4-d]pyrimidine, 2,8-dichloro-;8-dichloropyriMido[5;2,8-dichloro-[1,3]diazino[5,4-d]pyriMidine;4,6-Dichloropyrimido[5,4-d]pyrimidine
• CAS NO: 189747-34-0
• Molecular Formula: C₆H₂Cl₂N₄
• Molecular Weight: 201.01288
• Product Categories: CHIRAL CHEMICALS
• Mol File: 189747-34-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.67 g/cm³
• Refractive Index: 1.695
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: Pyrimido[5,4-d]pyrimidine, 2,8-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimido[5,4-d]pyrimidine, 2,8-dichloro-(189747-34-0)
• EPA Substance Registry System: Pyrimido[5,4-d]pyrimidine, 2,8-dichloro-(189747-34-0)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• RIDADR: UN2811
• Hazardous Substances Data: 189747-34-0(Hazardous Substances Data)

Usage

General Description

Pyrimido[5,4-d]pyrimidine, 2,8-dichloro- is a chemical compound with the molecular formula C6H2Cl2N4. It is a fused-ring heterocyclic compound consisting of two pyrimidine rings with chlorine atoms attached at the 2 and 8 positions. Pyrimido[5,4-d]pyrimidine, 2,8-dichloro- is a derivative of pyrimido[5,4-d]pyrimidine, which is known for its biological activities and potential pharmaceutical applications. The 2,8-dichloro- substitution may impart specific chemical or pharmacological properties to the molecule, making it suitable for research and potential drug development. Its structure and properties make it a valuable target for organic synthesis and medicinal chemistry studies.

InChI:InChI=1/C6H2Cl2N4/c7-5-4-3(10-2-11-5)1-9-6(8)12-4/h1-2H

Upstream product

• 65-86-1 orotic acid 
• 17687-24-0 5-nitroorotic acid 
• 52047-16-2 ethyl 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate 
• 54368-61-5 ethyl 2,4-dichloro-5-nitro-6-pyrimidinecarboxylic acid 
• 189747-29-3 5-amino-2-chloropyrimidine-4-carboxamide 
• 59950-50-4 ethyl 5-amino-2-chloropyrimidine-4-carboxylate 
• 189747-31-7 6-chloropyrimido[5,4-d]pyrimidin-4(3H)-one 

Downstream Products

• 189747-37-3 6-chloro-4-(phenylamino)pyrimido[5,4-d]pyrimidine 
• 189747-43-1 4-[(3-bromophenyl)amino]-6-chloropyrimido[5,4-d]pyrimidine 
• 189747-55-5 4-[(3-methylphenyl)amino]-6-chloropyrimido[5,4-d]pyrimidine 

Relevant articles and documents

NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds as inhibitors of receptor tyrosine kinases, in particular oncogenic mutants of ErbB-receptors e.g. in the treatment of cancer.