543683-36-9

Usage

Derivative of acetic acid

It is a modified version of acetic acid This means that the compound is structurally related to acetic acid, with some functional groups being modified or replaced.

Nitro group

Contains a nitro group (-NO2) The nitro group is a functional group consisting of an oxygen-nitrogen-oxygen chain (-O-N=O) that is attached to a carbon atom, which influences the chemical properties and reactivity of the compound.

Two fluorine atoms

Has two fluorine atoms attached to a phenyl ring The presence of fluorine atoms affects the compound's reactivity, electronegativity, and lipophilicity, making it more reactive and suitable for certain applications.

Phenyl ring

Contains a phenyl ring The phenyl ring is a six-membered carbon ring with alternating single and double bonds, which is a fundamental structure in many organic compounds.

Intermediate in synthesis

Used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals This means that the compound serves as a starting material or building block in the production of other chemicals, such as drugs and pesticides.

Reagent in organic chemistry

Used as a reagent in organic chemistry reactions The compound is used to facilitate or participate in chemical reactions, often to introduce or modify functional groups in other molecules.

Diverse applications

Applications extend to industries such as medicine, agriculture, and research The compound is used in a wide range of fields, including the development and production of pharmaceuticals, agrochemicals, and other organic compounds for research purposes.

Upstream product

• 66684-58-0 3,4,5-trifluoronitrobenzene 
• 105-53-3 diethyl malonate 

Downstream Products

• 1426802-80-3 C₂₃H₁₇ClF₅NO₄S 
• 1426805-37-9 2-(4-(ethylsulfonyl)-2,6-difluorophenyl)acetic acid 
• 1001755-64-1 2-(4-amino-2,6-difluorophenyl)acetic acid 
• 1426805-33-5 2-(4-((ethoxycarbonothioyl)thio)-2,6-difluorophenyl)acetic acid 
• 1426805-34-6 2-(2,6-difluoro-4-mercaptophenyl)acetic acid 
• 1426805-35-7 ethyl 2-(4-(ethylthio)-2,6-difluorophenyl)acetate 
• 1426805-36-8 ethyl 2-(4-(ethylsulfonyl)-2,6-difluorophenyl)acetate 

Relevant academic research and scientific papers

COMPOUNDS FOR TARGETED DEGRADATION OF BRD9

BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.

Discovery of [cis -3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H -inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, selective, and orally available novel retinoic acid rece

A series of tetrahydronaphthyridine derivatives as novel RORγt inverse agonists were designed and synthesized. We reduced the lipophilicity of tetrahydroisoquinoline compound 1 by replacement of the trimethylsilyl group and SBDD-guided scaffold exchange,

Heterocyclic compound

The present invention relates to compound (I) or a salt thereof which has a ROR γ t inhibitory action. wherein each symbol is as defined in the specification.

HETEROCYCLIC COMPOUNDS AND THEIR USE AS RETINOID-RELATED ORPHAN RECEPTOR (ROR) GAMMA-T INHIBITORS

Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

NOVEL COMPOUNDS

Disclosed are novel retinoid-related orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.

CYCLOPROPYL CONTAINING OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF

This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobacterial species. The compounds are represented by structural formula I: 1its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof.