5437-99-0

Usage

Uses

Used in Pharmaceutical Industry:
8-nitroquinolin-6-ol is used as an intermediate in the synthesis of various pharmaceuticals for its potential therapeutic applications. Its antibacterial and antifungal properties make it a valuable component in the development of new drugs to combat infections.
Used in Dye Industry:
8-nitroquinolin-6-ol is utilized as an intermediate in the production of dyes due to its chemical properties. Its ability to form various organic compounds contributes to the creation of a wide range of dyes used in different industries.
Used in Organic Synthesis:
8-nitroquinolin-6-ol serves as a building block in organic synthesis, allowing for the development of new compounds and materials. Its versatility in forming different organic compounds makes it an essential component in various chemical reactions.
Used in Fluorescent Dyes Synthesis:
8-nitroquinolin-6-ol is used in the synthesis of fluorescent dyes, which have applications in various fields such as bioimaging, diagnostics, and sensing. Its unique properties contribute to the development of dyes with specific characteristics and functions.
Used as a Reagent in Organic Chemical Reactions:
8-nitroquinolin-6-ol is employed as a reagent in organic chemical reactions, facilitating specific transformations and processes. Its involvement in these reactions is crucial for the synthesis of desired products and the advancement of organic chemistry.

Upstream product

• 610-81-1 4-hydroxy-2-nitroaniline 
• 107-02-8 acrolein 
• 885-81-4 N-(4-ethoxy-2-nitrophenyl)acetamide 
• 282547-59-5 6-ethoxy-8-nitro-quinoline 
• 85-81-4 6-methoxy-8-nitroquinoline 
• 616-86-4 2-nitro-4-ethoxyaniline 

Downstream Products

• 282547-59-5 6-ethoxy-8-nitro-quinoline 

Relevant academic research and scientific papers

Cell-trappable quinoline-derivatized fluoresceins for selective and reversible biological Zn(II) detection

The synthesis and spectroscopic characterization of two new, cell-trappable fluorescent probes for Zn(II) are presented. These probes, 2-(4,5-bis(((6-(2- ethoxy-2-oxoethoxy)quinolin-8-yl)amino)methyl)-6-hydroxy-3-oxo-3H-8 xanthen-9-yl)benzoic acid (QZ2E)

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER

This invention is in the field of medicinal chemistry. In particular, the invention relates to novel small molecule compounds having a quinolin-8-yl-nicotinamide structure which are useful in treating, ameliorating, or preventing various forms of cancer (e.g., pancreatic cancer).

Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}6 complex

The photo-initiated cytotoxicity of a newly developed manganese nitrosyl {MnNO}6 complex (UG1NO) to HeLa cells is described. The complex was found to be strongly cytotoxic after being exposed to light with a wavelength of 650 nm. Cell death was caused by a manganese(II) complex, UG1, generated from UG1NO through the photo-dissociation of NO, rather than by NO directly. Mechanistic studies revealed that UG1 consumes O2 only in the presence of a reducing agent to catalytically produce H2O2.

ANTI-CANCER AGENT, METAL COMPLEX AND HETEROCYCLE COMPOUND

PROBLEM TO BE SOLVED: To provide an anti-cancer agent which is inexpensive because of no use of expensive noble metal, and has mechanisms of action different from conventional platinum formulations. SOLUTION: An anti-cancer agent contains as an active ingredient a metal complex represented by the general formula (1) in the figure. (In the formula, R1 represents a hydrogen atom, a C1-C6 alkoxy group or an alkyl group or the like; R2 represents a hydrogen atom, a C1-C6 alkoxy group or the like; R3 to R10 represent hydrogen atoms or the like; M represents iron, manganese or cobalt; X represents a counter ion; and n represents 1 or 2.) COPYRIGHT: (C)2015,JPOandINPIT

SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I), and racemic and scalemic mixtures, diastereomers and enantiomers thereof: or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, prodrug or complex thereof, wherein Y, L, Z, W, M, Ra, Rb and Rc are as defined in the specification.

ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise (I) wherein: Ra, R1, R2 and R3 are each, independently, hydrogen, or a substituent selected from halogen, CF3, alkyl, alkoxy, MeSO2, amino or aminocarbonyl (each optionally substituted by one or two groups selected from alkyl and benzyl) carboxy, or alkoxycarbonyl; or two adjacent of Ra and R1-4 together can form a 5-7 membered carbocyclic or heterocyclic ring which is optionally substituted by a substituent defined above; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, arylalkyl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, alkoxy or benzyloxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is CH or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.