54376-50-0 Usage
Uses
Used in Pharmaceutical Research and Development:
Pyrimidine, 5-fluoro-2-methyl(9CI) is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the design and development of new drugs, potentially leading to the discovery of novel therapeutic agents.
Used in Agrochemical Synthesis:
In the agrochemical industry, Pyrimidine, 5-fluoro-2-methyl(9CI) is utilized as a building block in the creation of new agrochemical compounds. Its properties may contribute to the development of innovative products with improved efficacy and selectivity in crop protection and pest management.
Used in Medicinal Chemistry and Drug Discovery:
Pyrimidine, 5-fluoro-2-methyl(9CI) is employed as a research tool in medicinal chemistry to explore its potential biological activities. Its unique structure may provide insights into the development of new compounds with therapeutic potential, contributing to the advancement of drug discovery efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 54376-50-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,3,7 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 54376-50:
(7*5)+(6*4)+(5*3)+(4*7)+(3*6)+(2*5)+(1*0)=130
130 % 10 = 0
So 54376-50-0 is a valid CAS Registry Number.
54376-50-0Relevant academic research and scientific papers
Reactions of β-Fluorovinamidinium Salt with Bifunctional Hetero Nucleophiles. A New Synthetic Route to Fluorinated Heterocycles
Shi, Xifeng,Ishihara, Takashi,Yamanaka, Hiroki,Gupton, John T.
, p. 1527 - 1530 (2007/10/02)
β-Fluorovinamidium salt (2), readily prepared from N-(2,3,3-trifluoro-1-propenyl) trimethyl-ammonium iodide (1) and diethylamine, reacted with bifunctional hetero nucleophiles such as amidine and guanidine hydrochlorides in the presence of a base to afford regiospecifically monofluoronated pyrimidines 4 in good yields.The one-pot procedure starting from 1 was applicable for synthesizing heterocyclic compounds 4 in almost comparable yields.
Reactions of 1-Substituted-polyfluoro-1-propenyl p-Toluenesulfonates with Bifunctional Nitrogen Nucleophiles. A New Expedient Access to Monofluorinated Nitrogen Heterocycles
Funabiki, Kazumasa,Ohtsuki, Tetsuya,Ishihara, Takashi,Yamanaka, Hiroki
, p. 239 - 240 (2007/10/02)
1-Substituted-2,3,3-trifluoro-1-propenyl p-toluenesulfonates, readily available by the alkylation or arylation of 2,3,3-trifluoro-1-tosyloxy-1-propenyllithium or -zinc reagent, reacted smoothly with amidine or hydrazine derivatives at 70 deg C for 1h to give the corresponding 5-fluoropyrimidine or 4-fluoropyrazole compounds, respectively, in moderate to excellent yields.
