5438-08-4

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 495-69-2 Hippuric Acid 
• 1199-01-5 2-phenylazlactone 
• 108-24-7 acetic anhydride 
• 2373-74-2 2-benzoylamino-5-phenyl-penta-2,4-dienoic acid 
• 104-55-2 3-phenyl-propenal 
• 19746-93-1 6-phenyl-4-(3-phenyl-allylidene)-3,4-dihydro-[1,3,5]oxadiazin-2-one 
• 98-88-4 benzoyl chloride 

Downstream Products

• 2373-74-2 2-benzoylamino-5-phenyl-penta-2,4-dienoic acid 
• 37009-84-0 5,5-dimethyl-2-phenyl-4-(3-phenyl-allylidene)-4,5-dihydro-oxazole 
• 139596-86-4 N-{5-Oxo-2-phenyl-4-[(E)-3-phenyl-prop-2-en-(Z)-ylidene]-4,5-dihydro-imidazol-1-yl}-isonicotinamide 
• 138973-03-2 C₄₄H₃₂N₈O₂ 
• 132653-56-6 2-(cinnamyl)-2-benzamidoethylamine 
• 97856-49-0 2-Benzoylamino-3-styryl propene-1-ol 
• 621-82-9 Cinnamic acid 
• 75990-21-5 5-[(E)-3-Phenyl-prop-2-en-(E)-ylidene]-pyrrolidine-2,4-dione 
• 75990-27-1 4-Methoxy-5-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-1,5-dihydro-pyrrol-2-one 
• 75990-03-3 4-Hydroxy-2-oxo-5-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-2,5-dihydro-1H-pyrrole-3-carbonitrile 
• 75990-11-3 4-Hydroxy-2-oxo-5-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 
• 75990-01-1 2-Amino-4-oxo-5-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-4,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 
• 75990-18-0 4-Methoxy-2-oxo-5-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 
• 132653-50-0 2-(cinnamyl)ethylenediamine 

Relevant academic research and scientific papers

Discovery of a necroptosis inhibitor improving dopaminergic neuronal loss after mptp exposure in mice

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by motor deficits correlated with progressive dopaminergic neuronal loss in the substantia nigra pars compacta (SN). Necroptosis is a caspase-independent f

Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of Multi-Substituted Δ2-Pyrrolines and Their Cytotoxicity

An efficient, metal free approach to synthesize multi-substituted Δ2-pyrroline derivatives by mild base catalyzed cyclocondensation of malononitrile with Erlenmeyer azlactones via 1,2 addition was developed. The modularity of this reaction was used to assemble a range of poly-substituted pyrrolines. Further, synthesized products were screened for cytotoxic properties on different cancer cell lines such as A549 (Human lung adenocarcinoma cells), HeLa (Human cervical adenocarcinoma cells), Jurkat (Human chronic myeloid leukemia cells) and K562 (Human leukemic T cell Lymphoblast cells). Among the synthesized library of compounds, 6f and 6q displayed potent cytotoxic activity.

Nanocrystalline titanium dioxide catalyst for the synthesis of azlactones

Titanium dioxide nanoparticles were prepared by a electrochemical reduction method using parameters such as current density, solvent polarity, distance between electrodes, and concentration of stabilizers to control the size of the nanoparticles. The nanoparticles were characterized by UV-Vis spectroscopy, X-ray diffraction, scanning electron microscopy and transmission electron microscopy, and their catalytic performance was tested for the synthesis of a series of 4-aryldiene-2-phenyl-5(4)-oxazolones from the cyclodehydration and condensation of the respective aldehyde, hippuric acid and acetic anhydride. Easy availability, reusability and eco-friendliness were some prominent features of the nanocrystalline titanium dioxide catalyst.

Sonochemical hot-spot assisted one-pot synthesis of 4-arylmethylidene-2- phenyl-4H-oxazol-5-ones using nano-mgo as an efficient catalyst

Twelve 4-arylmethylidene-2-phenyl-4H-oxazol-5-ones were prepared in excellent yield by sonicating a mixture of an araldehyde, hippuric acid and acetic anhydride in the presence of a green heterogeneous NanoMgO as a basic catalyst. The catalytic activity o

Ammonium metavanadate an efficient catalyst for Erlenmeyer synthesis

An efficient method to synthesize azalactone derivatives using ammonium metavanadate (NH4VO3) as catalyst was performed in the absence of solvent. This method is environmentally friendly and affords the product azalactones in high yi

Alum an efficient catalyst for erlenmeyer synthesis

A new and efficient method to synthesize azlactone derivatives using alum ascatalyst was performed in the absence of additional solvent. This method is environmentally friendly and affords the product azlactones in high yields after simple workup.

Synthesis and antimicrobial activity of some 2-phenyl-1-[4-phenyl-1,3- thiazol-2-yl]-4-(substituted benzylidene)- imidazoline-5-ones

A series of thiazolyl imidazolinones have been synthesized and screened for their antimicrobial activity. Few of the compounds have shown promising activity against Gram positive organisms when compared with the standard drug.

Montmorillonite K-10 mediated Erlenmeyer synthesis of 4-arylmethylene-2- phenyl-5(4H)-oxazolones

Aromatic aldehydes and hippuric acid in acetic anhydride undergoes classical Erlenmeyer synthesis in the presence of a catalytic amount of Montmorillonite K-10 to afford the corresponding azlactones in excellent yields with high selectivity. The azlactone

Efficient and chemoselective conversion of aryl aldehydes to their azalactones catalysed by Bi(III) salts under solvent free conditions

Bi(NO3)3.5H2O, Bi(TFA)3 and Bi(OTf)3 were found to be highly powerful and practical catalysts for the synthesis of azalactones under solvent free conditions with excellent yields. In addition, high ch

Anhydrous zinc chloride catalysed synthesis of 2-phenyl-4-arylidene-5(4H)-oxazolones

An improved procedure is reported for the synthesis of arylidene oxazolones from hippuric acid and aromatic aldehydes in the presence of acetic anhydride and anhydrous zinc chloride in 62-76percent yields.