5439-43-0Relevant academic research and scientific papers
Crystal form of N,N-diethyl-2-hydroxy-2-phenylacetamide as well as preparation method and application of crystal form
-
Page/Page column 6-8, (2020/09/23)
The invention relates to a crystal form of N,N-diethyl-2-hydroxy-2-phenylacetamide as well as preparation method and an application of crystal form. An X-ray powder diffraction pattern of the crystalform is shown in the specification, and has characterist
Method for the Production of 1,3-Dioxolane-2-Ones and Carboxylic Acid Esters by Means of Transacylation in Basic Reaction Conditions
-
Page/Page column 11, (2010/12/29)
The invention relates to a method for producing 1,3-dioxolane-2-ones of general formula (3) in basic reaction conditions by reesterifying the respective ester of general formula (1) in which R1 to R5 have the meanings indicated in the claims and the descr
A remarkable iodine-catalyzed protection of carbonyl compounds
Banik, Bimal K.,Chapa, Marin,Marquez, Jocabed,Cardona, Magda
, p. 2341 - 2343 (2007/10/03)
We report here a remarkably simple molecular iodine-catalyzed protection method for various carbonyl compounds as ketals in a general reaction. The iodine-catalyzed reaction of mandelic acid and lactic acid with several aldehydes has furnished a highly diastereoselective synthesis of cis and trans dioxolanones.
Rapid synthesis of substituted 5-phenyl-1,3-dioxolan-4-ones under microwave-induced solvent-free conditions
Ferrett, Rochelle R.,Hyde, Michael J.,Lahti, Kimberly A.,Friebe, Timothy L.
, p. 2573 - 2576 (2007/10/03)
Under microwave irradiation and without solvent, racemic and optically pure mandelic acid readily condenses with aldehydes and ketones to give 2-alkyl substituted 5-phenyl-1,3-dioxolan-4-ones in good yield.
Palladium-catalyzed allylation of α-hydroxy acids
Moorlag, Henk,Vries, Johannes G. de,Kaptein, Bernard,Schoemaker, Hans E.,Kamphuis, Johan,Kellogg, Richard M.
, p. 129 - 137 (2007/10/02)
Mandelic and lactic acids are converted to the 1,3-dioxolan-4-ones by treatment with acetone dimethyl acetal.Deprotonation followed by treatment with an allyl acetate and a catalytic amount (1 mol percent) of palladium catalyst afforded the allylated dioxolanones, which could be hydrolyzed to the corresponding α-allyl α-hydroxy acids.The lithium enolate of the dioxolanone of mandelic acid was also coupled with methallyl, cinnamyl, geranyl and (E)-1-methyl-2-butenyl acetates.The zinc enolate of the dioxolanone of lactic acid reacted smoothly with allyl acetate in a catalyzed reaction whereas no detectable reaction was observed when the lithium enolate was used.This appears to be the result of complications arising from the enhanced basicity of the lithium compared to zinc enolate.Various attempts were made to achieve enantioselectivity using chiral ligands on the palladium catalyst.The zinc enolates were found to provide better results although the enantioselectivity was only modest, about 30percent enantiomeric excess being the best result obtained.Chiraphos proved to be the best optically active ligand of a variety tested.
Flash Vacuum Thermolysis of 1,3-Dioxolan-4-ones
Cameron, Tim B.,El-Kabbani, Fiesal M.,Pinnick, Harold W.
, p. 5414 - 5417 (2007/10/02)
Flash vacuum thermolysis of 1,3-dioxolane-4-ones yields aldehydes and ketones as the major products as the result of apparent decarboxylation of α lactones formed by collapse of a 1,3 dipole.When phenyl substituents are present, epoxides are also formed via the intermediacy of a carbonyl ylide.
