2019-69-4

Usage

Uses

Used in Recreational Settings:
Mandelic Acid Diethylamide is used as a recreational drug for its ability to induce a sense of empathy, emotional openness, and heightened sensory perception. Its hallucinogenic and euphoric effects are sought after by some individuals for their psychological and perceptual alterations.
Used in Research and Development:
Although not explicitly mentioned in the provided materials, MDA, like other psychoactive substances, may be used in scientific research to study the effects of amphetamines on the human brain and nervous system. This can contribute to the development of new treatments for various neurological and psychiatric disorders.

InChI:InChI=1/C12H17NO2/c1-3-13(4-2)12(15)11(14)10-8-6-5-7-9-10/h5-9,11,14H,3-4H2,1-2H3

Upstream product

• 2431-96-1 N,N-diethylphenylacetamide 
• 51170-56-0 diethylcarbamic acid benzyl ester 
• 100-52-7 benzaldehyde 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 4358-87-6 (RS)-methyl mandelate 
• 109-89-7 diethylamine 
• 34906-86-0 N,N-diethyl-2-oxo-2-phenylacetamide 
• 100-51-6 benzyl alcohol 
• 5439-43-0 3-phenyl-1,4-dioxaspiro<4,5>decan-2-one 
• 93799-43-0 mandelic acid N-hydroxysuccinimido ester 
• 1035803-72-5 Phenyl-trimethylsilanyloxy-acetyl chloride 
• 611-71-2 MANDELIC ACID 

Relevant academic research and scientific papers

Photoreduction of α-ketoamides; cyclization of unsaturated captodative radicals

When N-allyl α-ketoamides are irradiated in the presence of t-amines, a reductive photocyclization to hydroxypyrrolidones is observed. The reaction involves cyclization of an unsaturated captodative radical.

Hydrogenation of the carbonyl group in α-ketoesters and α-ketoamides catalyzed by ruthenium clay

Ruthenium clay, prepared by reaction of RuCl3·H2O with the 3- phosphinopropyl ligand anchored on Fluka K10 montmorillonite, is an effective catalyst for the reduction of the α-carbonyl group of α-ketoesters and α- ketoamides (50-89% yield).

Crystal form of N,N-diethyl-2-hydroxy-2-phenylacetamide as well as preparation method and application of crystal form

The invention relates to a crystal form of N,N-diethyl-2-hydroxy-2-phenylacetamide as well as preparation method and an application of crystal form. An X-ray powder diffraction pattern of the crystalform is shown in the specification, and has characterist

Preparation method of N,N-diethyl-2-hydroxyl-2-phenylacetamide

The invention provides a synthesis method of N,N-diethyl-2-hydroxyl-2-phenylacetamide. The N,N-diethyl-2-hydroxyl-2-phenylacetamide is obtained by condensing mandelic acid, serving as a raw material,with N-hydroxysuccinimide, and then performing substitut

Hydroxylation of carbanions with lithium teri-butyl peroxide acting as an oxenoid

The lithium salt of terf-butyl hydroperoxide can convert alkyl, vinyl, aryl carbanions, acetylides and various enolates into the corresponding hydroxylated derivatives in good yields and under mild conditions. Eisevier.

Directed Metalation/Snieckus Rearrangement of O-Benzylic Carbamates

Benzylic carbamates undergo 1,2- and 1,4-carbamoyl migration reaction after lithiation with s-BuLi or LDA in THF.

A one pot procedure for the synthesis of α-hydroxyamides from the corresponding α-hydroxyacids

α-Hydroxyamides are synthesized from the corresponding α-hydroxyacids by generation of the bis-trimethylsilyl derivative and treating it with oxalyl chloride. Following addition of the appropriate amine, the TMS ether is hydrolized in the workup to provid

Carbmoyllithiums. A Novel Method for Generation by Lithium-Tellurium Exchange Reaction

Reaction of Te-butyl carbamotelluroates with butyllithium at low temperatures resulted in efficient transmetallation to give corresponding carbamoyllithiums.A convenient one-pot procedure for nucleophilic carbamoylation using carbamoyl halides has been developed as an application of this reaction.

Direct Aminolysis of Nonactivated and Thermally Unstable Esters at High Pressure

The preparation of the amides 3 from a wide variety of nonactivated esters 1 and secondary amines 2 has been achieved at 8 kbar and around 45 deg C; scope and limitations are discussed.The method was also successfully applied for the aminolysis of alkyl 2-arylsulfinylacetates 7 that are relatively sensitive to heat. - Key Words: Aminolysis/ High-pressure synthesis

Electrogenerated Bases. VI. Reaction of Electrogenerated Superoxide with Some Carbon Acids. II.

Electrogenerated superoxide and molecular oxygen were allowed to react sequentially with a number of esters, nitriles, N,N-dialkylamides, sulfones, and aliphatic nitro compounds.The α-methyl groups in these compounds bore aliphatic and/or aromatic substituents.When the electron-withdrawing group (EWG) of these carbon acids could be displaced intact (nitile 2, ArSO2 4, nitro) good to excellent yields of the corresponding carbonyl compounds could be obtained.The efficiency of the transformation depended upon the nature of the substituents: α,α-diphenyl (e.g., 2a) > α-methyl-α-phenyl (2b) > α,α-dimethyl.By conducting the electrolysis in the presence of acetic anhydride it was shown that the known conversion of phenylacetonitrile (2d) to benzoic acid did indeed proceed via benzaldehyde.When the EWG itself could be cleaved (esters 1, N,N-dialkyl-amides 3), this methodology produced α-hydroxylated compounds and the products resulting from fragmentation of the EWG and also from its complete displacement.The effects of the α-substituents were similar to those above.