54396-39-3Relevant articles and documents
How Many O-Donor Groups in Enterobactin Does It Take to Bind a Metal Cation?
Baramov, Todor,Schmid, Bianca,Ryu, Ho,Jeong, Jinhoon,Keijzer, Karlijn,von Eckardstein, Leonard,Baik, Mu-Hyun,Süssmuth, Roderich D.
supporting information, p. 6955 - 6962 (2019/04/17)
The E. coli siderophore enterobactin, the strongest FeIII chelator known to date, forms hexacoordinate complexes with SiIV, GeIV, and TiIV. Synthetic protocols have been developed to prepare non-symmetric entero
HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues
Xia, Yan,Jin, Yinglan,Kaur, Navneet,Choi, Yongseok,Lee, Kyeong
supporting information; experimental part, p. 2386 - 2396 (2011/06/21)
The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold. Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1α protein accumulation and target gene expression under hypoxia.