1310328-54-1

Basic information

• Product Name: 3-benzyloxy-benzoic acid 3-hydroxy-2,2-dimethyl-chroman-7-yl ester
• Synonyms: 3-benzyloxy-benzoic acid 3-hydroxy-2,2-dimethyl-chroman-7-yl ester
• CAS NO: 1310328-54-1
• Molecular Weight: 404.463
• Mol File: 1310328-54-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-benzyloxy-benzoic acid 3-hydroxy-2,2-dimethyl-chroman-7-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyloxy-benzoic acid 3-hydroxy-2,2-dimethyl-chroman-7-yl ester(1310328-54-1)
• EPA Substance Registry System: 3-benzyloxy-benzoic acid 3-hydroxy-2,2-dimethyl-chroman-7-yl ester(1310328-54-1)

Safety Data

• Hazardous Substances Data: 1310328-54-1(Hazardous Substances Data)

Upstream product

• 288268-46-2 1-(hydroxy-methyl)-2,5-di-tert-butoxycarbonyloxy-benzene 
• 288268-32-6 bis-(2,4-tert-butoxycarbonyloxy)-benzaldehyde 
• 346433-57-6 carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 99-06-9 3-Carboxyphenol 
• 100-39-0 benzyl bromide 
• 54396-39-3 3-Benzyloxy-benzoic acid benzyl ester 
• 69026-14-8 3-benzyloxybenzoic acid 
• 1310328-60-9 carbonic acid tert-butyl ester 3-hydroxy-2,2-dimethylchroman-7-yl ester 

Relevant articles and documents

HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues

The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold. Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1α protein accumulation and target gene expression under hypoxia.