54397-16-9

Upstream product

• 106-49-0 p-toluidine 
• 2272-45-9 benzal-p-toluidine 
• 2101-86-2 p-methylazidobenzene 
• 100-52-7 benzaldehyde 
• 68-11-1 mercaptoacetic acid 

Downstream Products

• 10205-58-0 6-methyl-2-phenyl-1,3-benzothiazole 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 
• 614-96-0 5-methyl-1H-indole 
• 122-00-9 para-methylacetophenone 
• 103-89-9 4-Methylacetanilide 
• 134-81-6 benzil 
• 130887-92-2 2-phenyl-3-(4-methylphenyl)-5-phenylmethylene-4-oxo-1,3-thiazolidine 
• 130887-95-5 2-phenyl-3-(4-methylphenyl)-5-phenylmethylene-4-oxo-1,3-thiazolidine-1-oxide 
• 130888-00-5 2-phenyl-3-(4-methylphenyl)-5-(α-phenylmethylbenzyl)-4-oxo-1,3-thiazolidine-1-oxide 
• 130887-98-8 2-phenyl-3-(4-methylphenyl)-5-(α-phenylmethylaminobenzyl)-4-oxo-1,3-thiazolidine-1-oxide 
• 1353992-42-3 5-(4-dimethylaminobenzylidene)-2-phenyl-3-(4-methyphenyl)-4-thiazolidinone 
• 1353992-43-4 2-phenyl-5-(3-phenylallylidene)-3-(4-methyphenyl)-4-thiazolidinone 
• 1353992-40-1 5-(4-methoxybenzylidene)-2-phenyl-3-(4-methyphenyl)-4-thiazolidinone 
• 1353992-38-7 5-(4-chlorobenzylidene)-2-phenyl-3-(4-methyphenyl)-4-thiazolidinone 

Relevant academic research and scientific papers

Condensation–cyclization reaction for one-pot synthesis of 1,3-thiazolidin-4-one derivatives by poly(p-phenylenediamine) grafted on LDHs as a catalyst with green tool

The three-component reaction between amine, carbonyl compound and thioglycolic acid is now considered as a major strategy for synthesis of 1,3-thiazolidin-4-ones, which consists of the following steps: (i) condensation of aldehyde and amine which results

Preparation of thiazolidin-4-one derivatives using ZnO–NiO–NiFe2O4 nano-composite system

The hydrothermal synthesis of ZnO–NiO–NiFe2O4 nano-composite is reported. The sample was utilized to characterize via XRD, FE-SEM, EDS, FT-IR, UV–Vis, and BET techniques. The sample consisted of three different phases as ZnO (hexagonal), NiO (cubic), and NiFe2O4 (cubic) with the average particle size as 34?nm and specific surface area, average pore diameter, and pore volume as 64.35?m2?g?1, 13.02?nm, and 0.201?cm3?g?1, respectively. Catalytic behavior of the nano-composite was investigated on the synthesis of thiazolidin-4-one derivatives under thermal and ultrasonic irradiation condition. Our results show that the catalytic activity of ZnO–NiO–NiFe2O4 nano-composite is much higher than ZnO, NiO, and NiFe2O4 metal oxides. All products were prepared in high yields with short reaction times. In addition, the catalyst was recovered for at least five times.

Visible-light-driven photocatalytic activity of ZnO/g-C3N4 heterojunction for the green synthesis of biologically interest small molecules of thiazolidinones

Designing a photocatalytic system with complementary properties including high surface area, high loading, extraordinary electronic properties, and easy separation for increases photocatalytic performance has remained a challenge in photocatalytic applications. Herein, an environmentally benign approach was developed to fabricate graphitic carbon nitride (g-C3N4) decorated with nanorods zinc oxide (ZnO). The photocatalytic activity of ZnO decorated on the g-C3N4 surface was developed in the synthesis of 1,3-thiazolidin-4-ones and bis-thiazolidinones under very mild and sustainable reaction conditions. The reaction can be carried out by utilizing visible light without the requirement of any additive and other external sources of energy. It was found that the proposed photocatalyst is a more facile, recyclable, large-scale application and provides some new insights into the stabilization of semiconductors for a variety of applications.

Tromethamine organocatalyzed efficient tandem-multicomponent synthesis of new thiazolyl-4-thiazolidinones in aqueous medium

The catalytic potential of tris(hydroxymethyl)aminomethane (Tromethamine) has been assessed for the one pot three component tandem reaction involving a thiazolylmethoxy phenyl/aromatic carboxaldehyde, substituted amines and thioglycolic acid to form new t

TS-1 zeolite as a Lewis acid catalyst for solvent-free one-pot synthesis of 1,3-thiazolidin-4-ones

Abstract: Titanium silicate (TS-1) zeolite heterogeneous catalyst is synthesized by the hydrothermally discontinuous method and is characterized by using XRD, SEM, TEM, and NH3–TPD techniques. The catalytic activity of the TS-1 type zeolite was tested for one-pot solvent-free synthesis of 1,3-thiazolidine-4-ones. The present technique illustrates many benefits, including eco-friendly reaction conditions, environmentally helpful, short response time, simplicity, straightforward separatation, catalyst reusability and high yields of the products. Furthermore, the catalyst was utilized for four recycle reactions and it has been found that the catalyst shows consistent chemical process activity. Graphical abstract: [Figure not available: see fulltext.].

Graphene oxide catalyzed C-N/C-S/[3+2] cyclization cascade for green synthesis of thiazolidinone in water

In this paper, first graphene oxide catalyzed one-pot three-component green synthesis of 1,3- thiazolidin-4-one using amine, aldehyde and mercapto acetic acid in water has been reported. The reaction is affected via sequential C-N and C-S bond formation a

Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents

We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116.

A catalysis study of mesoporous MCM-41 supported Schiff base and CuSO4·5H2O in a highly regioselective synthesis of 4-thiazolidinone derivatives from cyclocondensation of mercaptoacetic acid

Mesoporous MCM-41 supported Schiff base and CuSO4·5H2O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines (or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving two-components or three-components afforded the desired product in high yields (up to 98% and 99%). Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.

Preparation of 2,3-diarylthiazolidin-4-one derivatives using barium molybdate nanopowders

Barium molybdate (BaMoO4) nanopowder was successfully synthesized via a simple precipitation route without any surfactant. The prepared nanopowder was applied for the facile synthesis of 2,3-diarylthiazolidin-4-one derivatives using cyclization

A facile and effective procedure for the synthesis of 4-thiazolidinone derivatives using Y(OTf)3 as catalyst

ABSTRACT: A one-pot three-component reaction for the synthesis of 4-thiazolidinone derivatives has been established by reacting readily available and inexpensive starting materials of amines, aldehydes and thioglycolic acid using Y(OTf)3 (5 mol%) as catalyst in tetrahydrofuran. This method is very efficient due to low catalyst loading and mild reaction conditions and provides an efficient and promising synthetic strategy for the construction of the thiazolidinone skeleton.