54397-17-0

Upstream product

• 100-52-7 benzaldehyde 
• 106-47-8 4-chloro-aniline 
• 68-11-1 mercaptoacetic acid 
• 126079-77-4 [(4-Chloro-phenylamino)-phenyl-methylsulfanyl]-acetic acid 
• 1613-89-4 (E)-N-benzylidene-4-chloroaniline 
• 780-21-2 N-(4-chlorobenzylidene)aniline 

Downstream Products

• 117682-44-7 4-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-5-phenyl-4,5-dihydro-3H-thiazolo[4,5-d]thiazole-2-thione 
• 117664-61-6 (4-Fluoro-phenyl)-dithiocarbamic acid 3-(4-chloro-phenyl)-4-oxo-2-phenyl-thiazolidin-5-yl ester 
• 117664-69-4 [6-(4-Chloro-phenyl)-5-phenyl-5,6-dihydro-1-oxa-3,4-dithia-6-aza-pentalen-(2E)-ylidene]-(4-fluoro-phenyl)-amine 
• 117664-65-0 [6-(4-Chloro-phenyl)-5-phenyl-5,6-dihydro-[1,3]dithiolo[4,5-d]thiazol-(2E)-ylidene]-(4-fluoro-phenyl)-amine 
• 117664-58-1 5-Bromo-3-(4-chloro-phenyl)-2-phenyl-thiazolidin-4-one 
• 54690-98-1 3-(4-chloro-phenyl)-5-(4-dimethylamino-benzylidene)-2-phenyl-thiazolidin-4-one 

Relevant academic research and scientific papers

CoFe2O4@SiO2/PrNH2 nanoparticles as highly efficient and magnetically recoverable catalyst for the synthesis of 1,3-thiazolidin-4-ones

An efficient three-component synthesis of 1,3-thiazolidin-4-ones is described by one-pot condensation of aldehydes, aromatic amine and thioglycolic acid with nano-CoFe2O4@SiO2/PrNH2 as a robust heterogeneous catalyst. The significant advantages of this protocol are the use of magnetically recoverable catalyst, high to excellent product yields, operational simplicity and the use of CoFe2O4@SiO2/PrNH2 nanoparticles as an environment-friendly catalyst.

Preparation of thiazolidin-4-one derivatives using ZnO–NiO–NiFe2O4 nano-composite system

The hydrothermal synthesis of ZnO–NiO–NiFe2O4 nano-composite is reported. The sample was utilized to characterize via XRD, FE-SEM, EDS, FT-IR, UV–Vis, and BET techniques. The sample consisted of three different phases as ZnO (hexagonal), NiO (cubic), and NiFe2O4 (cubic) with the average particle size as 34?nm and specific surface area, average pore diameter, and pore volume as 64.35?m2?g?1, 13.02?nm, and 0.201?cm3?g?1, respectively. Catalytic behavior of the nano-composite was investigated on the synthesis of thiazolidin-4-one derivatives under thermal and ultrasonic irradiation condition. Our results show that the catalytic activity of ZnO–NiO–NiFe2O4 nano-composite is much higher than ZnO, NiO, and NiFe2O4 metal oxides. All products were prepared in high yields with short reaction times. In addition, the catalyst was recovered for at least five times.

Visible-light-driven photocatalytic activity of ZnO/g-C3N4 heterojunction for the green synthesis of biologically interest small molecules of thiazolidinones

Designing a photocatalytic system with complementary properties including high surface area, high loading, extraordinary electronic properties, and easy separation for increases photocatalytic performance has remained a challenge in photocatalytic applications. Herein, an environmentally benign approach was developed to fabricate graphitic carbon nitride (g-C3N4) decorated with nanorods zinc oxide (ZnO). The photocatalytic activity of ZnO decorated on the g-C3N4 surface was developed in the synthesis of 1,3-thiazolidin-4-ones and bis-thiazolidinones under very mild and sustainable reaction conditions. The reaction can be carried out by utilizing visible light without the requirement of any additive and other external sources of energy. It was found that the proposed photocatalyst is a more facile, recyclable, large-scale application and provides some new insights into the stabilization of semiconductors for a variety of applications.

Silica chloride (SiO2-Cl) catalyzed one pot synthesis of 2,3-disubstituted-thiazolidin-4-one

In this paper, we report one-pot, three-component cyclo condensation of an aldehyde, an amine and thioglycolic acid to form 2,3-disubstituted-thiazolidin-4-one by using supported protic acid (Silica Chloride: SiO2-Cl) catalyst. The catalyst SiO2-Cl is compatible with a variety of aldehydes (aryl/heteroaryl) and the aromatic amines affording 2,3-disubstituted-thiazolidin-4-one analogs in 72–89% yields. Moreover, the supported catalyst was recycled several times without significant loss of catalytical activity.

TS-1 zeolite as a Lewis acid catalyst for solvent-free one-pot synthesis of 1,3-thiazolidin-4-ones

Abstract: Titanium silicate (TS-1) zeolite heterogeneous catalyst is synthesized by the hydrothermally discontinuous method and is characterized by using XRD, SEM, TEM, and NH3–TPD techniques. The catalytic activity of the TS-1 type zeolite was tested for one-pot solvent-free synthesis of 1,3-thiazolidine-4-ones. The present technique illustrates many benefits, including eco-friendly reaction conditions, environmentally helpful, short response time, simplicity, straightforward separatation, catalyst reusability and high yields of the products. Furthermore, the catalyst was utilized for four recycle reactions and it has been found that the catalyst shows consistent chemical process activity. Graphical abstract: [Figure not available: see fulltext.].

A catalysis study of mesoporous MCM-41 supported Schiff base and CuSO4·5H2O in a highly regioselective synthesis of 4-thiazolidinone derivatives from cyclocondensation of mercaptoacetic acid

Mesoporous MCM-41 supported Schiff base and CuSO4·5H2O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines (or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving two-components or three-components afforded the desired product in high yields (up to 98% and 99%). Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.

Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents

We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116.

Pd nanoparticles: an efficient catalyst for the solvent-free synthesis of 2,3-disubstituted-4-thiazolidinones

Abstract: Palladium nanoparticles (Pd NPs: ~5-nm diameter) catalysed an efficient, solvent-free protocol for the cyclocondensation reaction of the aldehydes, anilines and mercaptoacetic acid has been developed. This method offers a rapid, relatively economical and ecofriendly protocol for the synthesis of 2,3-disubstituted-4-thiazolidinones for the first time. Moreover, the catalyst can also be easily recovered and recycled with no loss of catalytic activity. Graphical Abstract: [Figure not available: see fulltext.]

Preparation of 2,3-diarylthiazolidin-4-one derivatives using barium molybdate nanopowders

Barium molybdate (BaMoO4) nanopowder was successfully synthesized via a simple precipitation route without any surfactant. The prepared nanopowder was applied for the facile synthesis of 2,3-diarylthiazolidin-4-one derivatives using cyclization

One-pot rapid synthesis of thiazole-substituted pyrazolyl-4-thiazolidinones mediated by diisopropylethylammonium acetate

A convenient one-pot, rapid and scalable synthetic protocol has been developed for recently reported anti-inflammatory agents, thiazole-substituted pyrazolyl-4-thiazolidinones. Quantitative multicomponent cyclocondensation of 3-(4-methyl-2-substituted thi