5440-33-5

Usage

General Description

2-acetamido-5-methylhexanoic acid is an organic compound with the molecular formula C10H19NO3. It is a derivative of valproic acid, a medication used to treat epilepsy, bipolar disorder, and migraines. The compound is an intermediate in the synthesis of valproic acid, and it is also used as a building block in organic synthesis. It is a white solid that is soluble in water and has a characteristic odor. In addition to its pharmaceutical applications, 2-acetamido-5-methylhexanoic acid is also used in the production of various chemicals and materials and has potential applications in the field of medicine and biotechnology.

Upstream product

• 107-82-4 i-pentyl bromide 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 3558-32-5 DL-leucine 
• 108-24-7 acetic anhydride 
• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 556-82-1 3-methyl-2-buten-1-ol 
• 105746-99-4 3,10-diethyl-3,6,10-trimethyl-4,9-dioxa-3,10-disiladodecane 
• 115-18-4 2-methyl-3-buten-2-ol 
• 1119-16-0 isocaproic aldehyde 
• 78-79-5 isoprene 
• 503-60-6 3,3-dimethyl-allyl chloride 
• 67688-65-7 2-Acetylamino-2-(3-benzylsulfanyl-3-methyl-butyl)-malonic acid diethyl ester 
• 67688-64-6 2-Acetylamino-5-benzylsulfanyl-5-methyl-hexanoic acid 

Downstream Products

• 117560-22-2 (S)-2-Amino-5-methyl-hexanoic acid benzyl ester; compound with toluene-4-sulfonic acid 
• 31872-98-7 L-2-amino-5-methyl hexanoic acid 

Relevant academic research and scientific papers

Studies on Angiotensin Converting Enzyme Inhibitors. 4. Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of 3-Acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic Acid Derivatives

(4S)-1-Alkyl-3-acyl>-2-oxoimidazolidine-4-carboxylic acid derivatives (3) were prepared by two methods.Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationships were discussed.The dicarboxylic acids 3a-n possessing S,S,S configuration showed potent in vitro ACE inhibitory activities with IC 50 values of 1.1x10-8-1.5x10-9 M.The most potent compound in this series, monoester 3p, had an ID 50 value of 0.24 mg/kg, po for inhibition of angiotensin I induced pressor response in normotensive rats and produced a dose-dependent decrease in systolic blood pressure of spontaneously hypertensive rats (SHRs) at doses of 1-10 mg/kg, po.

ON THE CATALYTIC AMIDOCARBONYLATION OF SUBSTITUTED ALLYLIC ALCOHOLS

Substituted allylic alcohols (3-methyl-2-buten-1-ol and 2-methyl-3-buten-2-ol) were isomerized and amidocarbonylated.In addition to the expected product, N-acetylleucine, arising from their rearrengement to 3-methylbutanal and subsequent amidocarbonylation (22percent yield), we isolated two additional products (28percent yield).These were shown by spectroscopic methods and by syntheses, via amidocarbonylations of the respective aldehydes, to be 2-acetamido-5-methylhexanoic acid and 2-acetamido-4-methylhexanoic acid.Their formation is postulated to be the sequential result of (i) dehydration first to form isoprene, (ii) hydroformylation and hydrogenation of isoprene to give 3-methyl-1-pentanal and 4-methyl-1-pentanal, and (iii) aldehyde amidocarbonylation.Treatment of isoprene itself under the same conditions also gave these latter two acetylamino acids.