5440-44-8

Usage

Classification

Nonsteroidal anti-inflammatory drug (NSAID)

Common uses

Treating pain and inflammation, often prescribed for rheumatoid arthritis, osteoarthritis, and menstrual pain

Mechanism of action

Inhibits the production of prostaglandins, which are chemicals in the body that cause pain and swelling

Available forms

Oral tablets and capsules

Administration

Typically taken with food to prevent stomach upset

Side effects

Stomach ulcers, gastrointestinal bleeding, and increased risk of heart attack or stroke (particularly with long-term use or in higher doses)

Precautions

Use the medication only as directed by a healthcare professional and closely monitor for any adverse effects

InChI:InChI=1/C13H17NO3/c1-10(15)14-12(13(16)17)9-5-8-11-6-3-2-4-7-11/h2-4,6-7,12H,5,8-9H2,1H3,(H,14,15)(H,16,17)

Upstream product

• 52161-73-6 2-acetylamino-2-(3-phenyl-propyl)malonic acid diethyl ester 
• 637-59-2 1-Bromo-3-phenylpropane 
• 4392-24-9 Cinnamyl bromide 
• 101782-54-1 Acetamino-cinnamyl-malonsaeure-diethylester 
• 108246-15-7 (+/-)-4-Acetamino-1-phenyl-penten-⁽¹⁾-saeure-⁽⁵⁾ 
• 108019-30-3 DL-N-acetyl-2-amino-5-phenylpentanoic acid 
• 62732-55-2 2-Acetylamino-2-(3-phenyl-propyl)-malonic acid 

Downstream Products

• 106270-07-9 2-methyl-4-(3-phenyl-propyl)-4H-oxazol-5-one 

Relevant academic research and scientific papers

Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues

A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-d-Ser-aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the phenyl ring has been investigated, as well as replacements for the benzyl group and for the AIB residue. A number of modifications resulted in enhanced potency over the parent benzyl-d-Ser-AIB derivative.

Growth hormone secretagogues

What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C6H5CH2OCH2—, C6H5(CH2)3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C1-C6alkylpiperidin-1-yl or NR2R2; R2 are each independently a C1to C6alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6alkoxy or phenyl; and R4 is H or CH3, or a pharmaceutically acceptable salt or solvate thereof.

STEREOSELECTIVE PROCESS FOR THE SYNTHESIS OF (D)-2-AMINO-5-PHENYLPENTANOIC OR ALKYL ESTER THEREOF

The present invention provides a process for preparing a compound of formula (I); wherein R is a C1-C6 alkyl; or a salt thereof; comprising:(c) hydrolyzing (D,L)-N-acetyl-2-amino-5-phenylpentanoic acid with a suitable base in the pre

Treatment of congestive heart failure with growth hormone secretagogues

The present invention is directed to methods for the modulation of cardiac function which comprise the administration of certain compounds, as defined herein, having growth hormone secretagogue activity.