54402-13-0

Upstream product

• 1822-51-1 4-picolylchloride hydrochloride 
• 90-02-8 salicylaldehyde 
• 54751-01-8 4-(bromomethyl)pyridine 

Downstream Products

• 1416064-86-2 C₃₁H₄₀N₄O₃ 
• 7035-04-3 4-(benzofuran-2-yl)pyridine 
• 1549807-57-9 (4-methoxyphenyl)(2-(pyridin-4-ylmethoxy)phenyl)methanone 
• 54402-55-0 1-(2-(pyridin-4-ylmethoxy)phenyl)ethan-1-one 
• 1549807-89-7 4-(3-(4-methoxyphenyl)benzofuran-2-yl)pyridine 
• 1156177-80-8 1-(2-(pyridin-4-ylmethoxy)phenyl)ethan-1-ol 
• 1549808-84-5 (4-methoxyphenyl)(2-(pyridin-4-ylmethoxy)phenyl)methanol 

Relevant academic research and scientific papers

Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors

A series of benzofuran-based N-benzylpyridinium derivatives 5a-o were designed and synthesized as novel AChE inhibitors. The synthetic pathway of the compounds involved the preparation of 4-(benzofuran-2-yl)pyridine intermediates via the reaction of different salicylaldehyde derivatives and 4-(bromomethyl)pyridine, followed by intramolecular cyclization. Subsequently, the 4-(benzofuran-2-yl)pyridines were N-benzylated by using appropriate benzyl bromide to afford the final product 5a-o. The results of in vitro AChE activity evaluation of synthesized compounds revealed that all compound had potent anti-AChE activity comparable or more potent than standard drug donepezil. The N-(3,5-dimethylbenzyl) derivative 5e with IC50 value of 4.1 nM was the most active compound, being 7-fold more potent than donepezil.

NEW COMPOUNDS AND USES THEREOF FOR DETECTION OF TARGET MOLECULES IN A SAMPLE

The present invention relates to new profluorophores and conjugates thereof and their use for the detection of target molecule in a sample, in particular nucleic acid target molecules. The invention relates to new profluorophores and new fluorophores and methods of use thereof particularly useful in the fields of diagnostics and quality control.

Bronsted acid catalyzed intramolecular benzylic cyclizations of alkylpyridines

Aldehyde and ketone electrophiles incorporated into the side chains of 2- and 4-alkylpyridines participate in intramolecular aldol-like condensations with pyridine benzylic carbons in the presence of Bronsted acid catalysts. Pyridines featuring β-ketoamid

Inhibition of Ebola virus infection: Identification of niemann-pick C1 as the target by optimization of a chemical probe

A high-throughput screen identified adamantane dipeptide 1 as an inhibitor of Ebola virus (EboV) infection. Hit-to-lead optimization to determine the structure-activity relationship (SAR) identified the more potent EboV inhibitor 2 and a photoaffinity labeling agent 3. These antiviral compounds were employed to identify the target as Niemann-Pick C1 (NPC1), a host protein that binds the EboV glycoprotein and is essential for infection. These studies establish NPC1 as a promising target for antiviral therapy.

Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase

Inhibitors of protein farnesyl transferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating cancer, restenosis, psoriasis, endometriosis, atherosclerosis, or viral infe

Pyridine derivatives

The invention concerns novel, pharmaceutically useful 1,3-dioxane alkenoic acid derivatives of the formula I containing a pyridyl moiety at position 4 of the dioxane ring and in which the groups at positions 2, 4 and 5 have cis-relative stereochemistry, X is hydrogen, alkoxy or hydroxy, Y is vinylene, n is 1 or 2, A1 is alkylene, the substituents R1 and R2 at position 2 of the dioxane ring have a variety of values defined hereinafter, and R4 is hydroxy, a physiologically acceptable alcohol residue or alkanesulphonamido, and the pharmaceutically acceptable salts thereof. The invention also includes processes for the manufacture and use of the acid derivatives as well as pharmaceutical compositions for therapeutic use in one or more of a variety of diseases such as ischaemic heart disease, cerebrovascular disease, asthmatic disease and/or inflammatory disease.