7035-04-3

Basic information

• Product Name: Pyridarone
• Synonyms: Pyridarone;4-(2-benzofuranyl)pyridine;4-(1-benzofuran-2-yl)pyridine
• CAS NO: 7035-04-3
• Molecular Formula: C13H9NO
• Molecular Weight: 0
• Mol File: 7035-04-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 333.3°C at 760 mmHg
• Flash Point: 155.3°C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 0.000267mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: Pyridarone(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridarone(7035-04-3)
• EPA Substance Registry System: Pyridarone(7035-04-3)

Safety Data

• Hazardous Substances Data: 7035-04-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H9NO/c1-2-4-12-11(3-1)9-13(15-12)10-5-7-14-8-6-10/h1-9H

Upstream product

• 54751-01-8 4-(bromomethyl)pyridine 
• 1822-51-1 4-picolylchloride hydrochloride 
• 54402-13-0 2-[(pyridin-4-yl)-methyloxy]-benzaldehyde 
• 90-02-8 salicylaldehyde 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 18698-97-0 ortho-bromophenylacetic acid 
• 7048-30-8 1-acetoxy-2-(2-pyridin-4-yl-vinyl)-benzene 
• 742632-38-8 1-acetoxy-2-(2-bromo-2-pyridin-4-yl-vinyl)-benzene 
• 1570-45-2 isonicotinic acid ethylester 
• 7035-03-2 2-methoxy-benzeneacetonitrile 

Relevant articles and documents

Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors

A series of benzofuran-based N-benzylpyridinium derivatives 5a-o were designed and synthesized as novel AChE inhibitors. The synthetic pathway of the compounds involved the preparation of 4-(benzofuran-2-yl)pyridine intermediates via the reaction of different salicylaldehyde derivatives and 4-(bromomethyl)pyridine, followed by intramolecular cyclization. Subsequently, the 4-(benzofuran-2-yl)pyridines were N-benzylated by using appropriate benzyl bromide to afford the final product 5a-o. The results of in vitro AChE activity evaluation of synthesized compounds revealed that all compound had potent anti-AChE activity comparable or more potent than standard drug donepezil. The N-(3,5-dimethylbenzyl) derivative 5e with IC50 value of 4.1 nM was the most active compound, being 7-fold more potent than donepezil.

One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy

To access useful heterocycles in medicinal chemistry such as pyridazinones, dihydropyrimidinones, and dihydropyrimidinthiones, a "green" mild and highly efficient one-pot triple cascade was developed involving a Claisen-decarboxylation, electrophilic reaction, and subsequent heterocyclization. In addition, indazoles and benzofurans could also be constructed via a double cascade. To develop the cascade process, a direct Claisen-decarboxylation reaction was firstly optimized. This reaction can then couple with electrophilic reactions including alkylation, Michael addition or aldol reaction to enable the preparation of various aryl ketones in a one-pot fashion. The Royal Society of Chemistry 2012.