7035-04-3

Usage

InChI:InChI=1/C13H9NO/c1-2-4-12-11(3-1)9-13(15-12)10-5-7-14-8-6-10/h1-9H

Upstream product

• 1570-45-2 isonicotinic acid ethylester 
• 7035-03-2 2-methoxy-benzeneacetonitrile 
• 742632-38-8 1-acetoxy-2-(2-bromo-2-pyridin-4-yl-vinyl)-benzene 
• 7048-30-8 1-acetoxy-2-(2-pyridin-4-yl-vinyl)-benzene 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 18698-97-0 ortho-bromophenylacetic acid 
• 90-02-8 salicylaldehyde 
• 54402-13-0 2-[(pyridin-4-yl)-methyloxy]-benzaldehyde 
• 1822-51-1 4-picolylchloride hydrochloride 
• 54751-01-8 4-(bromomethyl)pyridine 

Relevant academic research and scientific papers

Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors

A series of benzofuran-based N-benzylpyridinium derivatives 5a-o were designed and synthesized as novel AChE inhibitors. The synthetic pathway of the compounds involved the preparation of 4-(benzofuran-2-yl)pyridine intermediates via the reaction of different salicylaldehyde derivatives and 4-(bromomethyl)pyridine, followed by intramolecular cyclization. Subsequently, the 4-(benzofuran-2-yl)pyridines were N-benzylated by using appropriate benzyl bromide to afford the final product 5a-o. The results of in vitro AChE activity evaluation of synthesized compounds revealed that all compound had potent anti-AChE activity comparable or more potent than standard drug donepezil. The N-(3,5-dimethylbenzyl) derivative 5e with IC50 value of 4.1 nM was the most active compound, being 7-fold more potent than donepezil.

Bronsted acid catalyzed intramolecular benzylic cyclizations of alkylpyridines

Aldehyde and ketone electrophiles incorporated into the side chains of 2- and 4-alkylpyridines participate in intramolecular aldol-like condensations with pyridine benzylic carbons in the presence of Bronsted acid catalysts. Pyridines featuring β-ketoamid

One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy

To access useful heterocycles in medicinal chemistry such as pyridazinones, dihydropyrimidinones, and dihydropyrimidinthiones, a "green" mild and highly efficient one-pot triple cascade was developed involving a Claisen-decarboxylation, electrophilic reaction, and subsequent heterocyclization. In addition, indazoles and benzofurans could also be constructed via a double cascade. To develop the cascade process, a direct Claisen-decarboxylation reaction was firstly optimized. This reaction can then couple with electrophilic reactions including alkylation, Michael addition or aldol reaction to enable the preparation of various aryl ketones in a one-pot fashion. The Royal Society of Chemistry 2012.