54524-31-1

Upstream product

• 59463-56-8 thioacetic acid S-cyanomethyl ester 

Downstream Products

• 77954-58-6 m-chlorothiobenzoic acid, S-cyanomethyl ester 
• 77954-59-7 4-Methyl-thiobenzoic acid S-cyanomethyl ester 
• 77954-61-1 2-Methyl-thiobenzoic acid S-cyanomethyl ester 
• 80737-85-5 2-((2-oxo-2-phenylethyl)thio)acetonitrile 
• 77954-60-0 3-Methyl-thiobenzoic acid S-cyanomethyl ester 
• 55453-24-2 4-(trimethoxysilyl)butanenitrile 
• 936716-45-9 4-amino-2-(4-[2-trifluoromethyl-phenoxy]piperidin-1-yl)-1,3-thiazole-5-carbonitrile 
• 1198565-35-3 C₁₃H₁₃NO₂S 
• 2046-18-6 4-phenylbutyronitrile 
• 74-90-8 hydrogen cyanide 
• 1209492-99-8 4-(allyloxy)-6-fluorobenzo[b]thiophene-2-carbonitrile 
• 1162196-87-3 2-(p-nitrophenyl)prop-2-enylthioacetonitrile 
• 1041195-42-9 (2,6-dinitrophenylsulfanyl)ethanenitrile 
• 1041195-43-0 (2,4,6-trinitrophenylsulfanyl)ethanenitrile 

Relevant academic research and scientific papers

5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS

The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

ARYL VINYL SULFIDES, SULFONES, SULFOXIDES AND SULFONAMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF

Compounds useful as antiproliferative agents, including, for example, anticancer agents, according to formula (I): wherein Ar1, Ar2, D, G, formula (a), m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, synthetic processes, and intermediates useful in such processes are provided.

HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISEASE

Heterocyclic compounds of the formula (I) are provided: wherein ring A, ring B, R1, R2, R3, R4, Y, m, n and q are as defined herein. R1 is in particular amidino. The invention further provides particular benzothiophene compounds. Compounds of the invention may be useful as inhibitors of Factor IXa and in the therapy of cardiovascular conditions and diseases, e.g. thrombosis.

Thiocyanohydrins, a new class of compounds, precursors of unstabilized thiocarbonyl derivatives

Mono- and dialkylated thiocyanohydrins are prepared by alkylation of the parent compound 2 (NCCH2SH) under mild conditions. Some examples of the reactivity of this new class of compounds are also given.