92014-05-6

Upstream product

• 1753-90-8 6-methoxy-1,2,3-benzothiadiazole 
• 72314-64-8 2-(t-butylthio)acrylonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 107-14-2 chloroacetonitrile 
• 54524-31-1 2-mercaptoacetonitrile 
• 331-64-6 2-fluoro-4-methoxy-benzaldehyde 
• 476199-19-6 dimethylthiocarbamic acid S-(2-formyl-5-methoxyphenyl) ester 
• 294674-98-9 2-mercapto-4-methoxybenzaldehyde 
• 590-17-0 cyanomethyl bromide 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 476199-18-5 dimethylthiocarbamic acid O-(2-formyl-5-methoxyphenyl) ester 

Downstream Products

• 217099-77-9 6-hydroxy-2-cyanobenzothiophene 

Relevant academic research and scientific papers

Novel heterocyclic analogues of firefly luciferin

Five novel firefly luciferin analogues in which the benzothiazole ring system of the natural substrate was replaced with benzimidazole, benzofuran, benzothiophene, benzoxazole, and indole were synthesized. The fluorescence, bioluminescence, and kinetic pr

HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISEASE

Heterocyclic compounds of the formula (I) are provided: wherein ring A, ring B, R1, R2, R3, R4, Y, m, n and q are as defined herein. R1 is in particular amidino. The invention further provides particular benzothiophene compounds. Compounds of the invention may be useful as inhibitors of Factor IXa and in the therapy of cardiovascular conditions and diseases, e.g. thrombosis.

3-ARYLOXY/ THIO-2, 3-SUBSTITUTED PROPANAMINES AND THEIR USE IN INHIBITING SEROTONIN AND NOREPINEPHRINE REUPTAKE

There is provided a compound of formula (I) wherein A is selected from -O- and -S-; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4 alkyl and C1-C4 alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C1-C4 alkyl, and C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, -CF3, -CN and -CONH2; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n- where n is 0, 1 or 2, nitro, acetyl, -CF3, -SCF3 and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1-C4 alkyl; Z is selected from OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1-C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereofwith the proviso that when Y is optionally substituted phenyl or optionally substituted 1,3-benzodioxolyl and Z is OR3 and X is optionally substituted phenyl then A is -S-.

Synthesis of substituted 2-mercaptobenzaldehydes and 2-substituted benzo[b]thiophenes

Simple and rapid single-pot preparations of substituted 2- mercaptobenzaldehydes 5 and 2-substituted benzo[b]thiophenes 3 based on ortho-lithiation methodology are described. (C) 2000 Elsevier Science Ltd.

Reaction of 1,2,3-Benzothiadiazoles with Radicophilic Alkenes and Alkynes in Di-tert-butyl Peroxide.

The reaction of 6-X-1,2,3-benzothiadiazoles (1) with the radicophilic alkenes 1,1-diphenylethylene (2) and 1-cyano-1-(tert-butylthio)ethylene (3) and the alkynes PhCCR (4, R=H or Ph) in di-tert-butyl peroxide (TBP) leads to the cycloadducts 5, 7, and 8.The proposed mechanism involves an initial attack by tert-butoxy radical at the sulfur atom of 1 affording the radical intermediate 9 which is responsible for the formation of all the reaction products.