545358-50-7

Basic information

• Product Name: 4-methyl-N-(2-thienylmethyl)benzenesulfonamide
• Synonyms: 4-methyl-N-(2-thienylmethyl)benzenesulfonamide
• CAS NO: 545358-50-7
• Molecular Formula: C₁₂H₁₃NO₂S₂
• Molecular Weight: 267.36712
• Mol File: 545358-50-7.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-methyl-N-(2-thienylmethyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(2-thienylmethyl)benzenesulfonamide(545358-50-7)
• EPA Substance Registry System: 4-methyl-N-(2-thienylmethyl)benzenesulfonamide(545358-50-7)

Safety Data

• Hazardous Substances Data: 545358-50-7(Hazardous Substances Data)

Upstream product

• 636-72-6 2-thiophenemethanol 
• 70-55-3 toluene-4-sulfonamide 
• 27757-85-3 2-Aminomethylthiophene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 29281-83-2 4-methylbenzensulphonamide potassium salt 
• 941-55-9 4-toluenesulfonyl azide 
• 71637-34-8 3-hydroxymethyl-thiophene 
• 158293-42-6 4-methyl-N-(thiophen-2-ylmethylene)benzenesulfonamide 
• 45438-73-1 2-thenyl bromide 
• 98-03-3 thiophene-2-carbaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 53039-61-5 2<(4-Methoxyphenyl)methyl>thiophene 
• 1333226-17-7 C₁₉H₁₉NO₄S₃ 
• 1527501-81-0 N-(1H-indol-2-yl)-4-methyl-N-(thiophen-2-ylmethyl)benzenesulfonamide 

Relevant articles and documents

Boron-Catalyzed N-Alkylation of Arylamines and Arylamides with Benzylic Alcohols

A sustainable boron-based catalytic approach for chemoselective N-alkylation of primary and secondary aromatic amines and amides with primary, secondary, and tertiary benzylic alcohols has been presented. The metal-free protocol operates at low catalyst loading, tolerates several functional groups, and generates H2O as the sole byproduct. Preliminary mechanistic studies were performed to demonstrate the crucial role of boron catalyst for the activation of the intermediate dibenzyl ether and to identify the rate-determining step.

Borinic Acid Mediated Hydrosilylations: Reductions of Carbonyl Derivatives

4-Fluoro-2-chlorophenylborinic acid acts as a precatalyst in the presence of phenylsilane for the facile reduction of ketones, aldehydes and imines. Notably, synergistic mediation of a tertiary amine was found essential to trigger silicon to boron hydride transfer to generate a key amine–diarylhydroborane Lewis complex.

Hydrogen autotransfer and related dehydrogenative coupling reactions using a rhenium(i) pincer catalyst

A novel rhenium complex bearing a non-innocent PNP pincer ligand was prepared. This novel catalyst is active in hydrogen autotransfer reactions to form new C-C and C-N bonds. More specifically, valuable alkylations of ketones and sulfonamides with primary alcohols are herein presented. In addition, the first examples of rhenium-catalysed synthesis of pyrroles are described by dehydrogenative coupling of diols, amines and ketones.