54538-01-1

Upstream product

• 62723-78-8 2-methoxymethylaniline 
• 21473-01-8 2-naphthalenylmagnesium bromide 
• 580-13-2 2-bromonaphthalene 
• 2506-41-4 1-chloromethylnaphthalene 
• 1218996-93-0 2-((naphthalen-2-yl)methyl)benzaldehyde 
• 40138-16-7 2-formylbenzene boronic acid 
• 5570-19-4 2-nitrophenylboronic acid 
• 1316859-57-0 2-(2-nitrobenzyl)naphthalene 
• 939-26-4 2-bromomethylnaphthyl bromide 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 408538-58-9 2-methoxymethyl-benzoic acid amide 
• 57991-54-5 2-(methoxymethyl)benzonitrile 
• 54537-96-1 (2-aminophenyl)(naphthalen-2-yl)methanone 

Downstream Products

• 68299-60-5 2-((naphthalen-2-yl)methyl)phenol 
• 205-12-9 benzo[c]fluorene 
• 613-59-2 2-benzylnaphthalene 

Relevant academic research and scientific papers

Synthesis of Benzoazepine Derivatives via Azide Rearrangement and Evaluation of Their Antianxiety Activities

A new synthetic method for the construction of benzoazepine analogues has been developed employing ortho-arylmethylbenzyl azide derivatives as precursors using an azide rearrangement reaction. In this work, 14 benzoazepine compounds were successfully synthesized in moderate to excellent yields. All synthetic benzoazepines were evaluated for their cytotoxicity against normal human kidney cell line (HEK cell). The results showed that compound 18c had the lowest cytotoxicity (IC50 = 65.68 μM) among tested compounds, which was comparable with the antianxiety drug diazepam (IC50 = 87.90 μM). Based on the cytotoxicity results, five benzoazepine analogues (compounds 18c, 18h, 18j, 18n, and 18p) were selected to determine the antianxiety effect on stressed rats using elevated plus maze (EPM) and open field test (OFT) methods. Interestingly, compound 18c showed better anxiolytic activity than diazepam without a sedative effect by showing superior hyperlocomotor activity. Therefore, this discovery could pave the way for drug development to treat patients with anxiety disorder.

Copper-Catalyzed One-Pot Synthesis of Dibenzofurans, Xanthenes, and Xanthones from Cyclic Diphenyl Iodoniums

Oxygenation of cyclic diphenyl iodoniums (CDPIs) with varied medium-ring sizes has been fully investigated. This practical copper-catalyzed tandem reaction of CDPIs with water as the oxygen source enables the construction of derivatised dibenzofurans and xanthenes at moderate to good yields. Moreover, structurally important xanthones are also successfully accessed under the oxygenation conditions with additional TEMPO.