6500-62-5Relevant academic research and scientific papers
Organoselenium-catalyzed enantioselective syn-dichlorination of unbiased alkenes
Gilbert, Bradley B.,Eey, Stanley T.-C.,Ryabchuk, Pavel,Garry, Olivia,Denmark, Scott E.
supporting information, p. 4086 - 4098 (2019/06/25)
The enantioselective dichlorination of alkenes is a continuing challenge in organic synthesis owing to the limitations of selective and independent antarafacial delivery of both electrophilic chlorenium and nucleophilic chloride to an olefin. Development of a general method for the enantioselective dichlorination of isolated alkenes would allow access to a wide variety of polyhalogenated natural products. Accordingly, the enantioselective suprafacial dichlorination of alkenes catalyzed by electrophilic organoselenium reagents has been developed to address these limitations. The evaluation of twenty-three diselenides as precatalysts for enantioselective dichlorination is described, with a maximum e.r. of 76:24 Additionally, mechanistic studies suggest an unexpected Dynamic Kinetic Asymmetric Transformation (DyKAT) process may be operative.
FUSED RING COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
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Page/Page column 85, (2008/06/13)
The invention relates to certain fused ring compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
Barium Permanganate, Ba(MnO4)2; An Efficient and Mild Oxidizing Agent for Use Under Non-aqueous and Aprotic Conditions
Firouzabadi, H.,Mottghinejad, E.,Seddighi, M.
, p. 378 - 380 (2007/10/02)
Barium permanganate is used for the efficient oxidation of different types of alcohols and acyloins to the corresponding carbonyl compounds in boiling acetonitrile.The mildness of this reagent is shown by the oxidative S,S-coupling of several thiols to disulfides.
