5454-04-6 Usage
Molecular structure
A complex chemical compound with a long and unique molecular structure.
Benzylamino group
A functional group consisting of a benzyl group (a phenyl ring attached to a methyl group) connected to an amino group (-NH2).
Hydroxy group
A polar functional group (-OH) that can form hydrogen bonds with other molecules.
Methylene group
A carbon-carbon single bond (-CH2-) that serves as a spacer between other functional groups in the molecule.
4H-1,2,4-triazol-3-yl group
A heterocyclic ring system consisting of a five-membered ring with three nitrogen atoms and two hydrogen atoms, which can contribute to the compound's chemical reactivity and stability.
Butanenitrile group
A functional group consisting of a four-carbon chain with a triple bond between the first and second carbon atoms, and a cyano group (-CN) attached to the second carbon.
2,4-dimethylphenyl group
A phenyl ring (a six-membered ring with alternating single and double carbon-carbon bonds) with two methyl groups (-CH3) attached to the second and fourth carbon atoms, which can influence the compound's steric properties and solubility.
Naphthalen-1-ylmethyl group
A naphthalene ring (a fused pair of phenyl rings) with a methyl group (-CH3) attached to the first carbon atom, which can contribute to the compound's lipophilicity and potential biological activity.
Sulfanyl group
A sulfur analog of a hydroxyl group (-SH) that can participate in redox reactions and coordinate with metal ions.
Potential applications
Due to its intricate structure and potentially diverse properties, this chemical may have various applications in fields such as medicine, biology, and chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 5454-04-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,5 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5454-04:
(6*5)+(5*4)+(4*5)+(3*4)+(2*0)+(1*4)=86
86 % 10 = 6
So 5454-04-6 is a valid CAS Registry Number.
5454-04-6Relevant articles and documents
Structure–activity relationships (SARs) of α- ketothioamides as inhibitors of phosphoglycerate dehydrogenase (PHGDH)
Spillier, Quentin,Ravez, Séverine,Unterlass, Judith,Corbet, Cyril,Degavre, Charline,Feron, Olivier,Frédérick, Rapha?l
, (2020/02/11)
For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments. Recently, numerous reports highlighted the crucial role of the serine synthetic pathway, and particularly of the phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the pathway, to sustain cancer progression. Yet, because of very weak potencies usually in cell-based settings, the inhibitors reported so far failed to lay ground on the potential of this approach. In this paper, we report a structure–activity relationship study of a series of α-ketothioamides that we have recently identified. Interestingly, this study led to a deeper understanding of the structure–activity relationship (SAR) in this series and to the identification of new PHGDH inhibitors. The activity of the more potent compounds was confirmed by cellular thermal shift assays and in cell-based experiments. We hope that this research will eventually provide a new entry point, based on this promising chemical scaffold, for the development of therapeutic agents targeting PHGDH.
Fe3+-exchanged clay catalyzed transamidation of amides with amines under solvent-free condition
Ayub Ali, Md.,Hakim Siddiki,Kon, Kenichi,Shimizu, Ken-Ichi
supporting information, p. 1316 - 1319 (2014/03/21)
Fe3+-exchanged montmorillonite is shown to be an effective and reusable heterogeneous catalyst for the transamidation of various amides and amines under solvent-free condition. The catalyst shows high yields and wide substrate scope.
