54544-67-1

Usage

Uses

Used in Pharmaceutical Industry:
Isoindolin-5-ol is used as a key intermediate in the synthesis of 6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists. These agonists possess potential antipsychotic properties, making them valuable in the development of new treatments for psychiatric disorders.
Used in Organic Synthesis:
Isoindolin-5-ol is also utilized in organic synthesis for the creation of various other compounds with diverse applications. Its unique structure allows for further functionalization and modification, contributing to the development of novel molecules with potential uses in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 127168-88-1 5-methoxy-2,3-dihydro-1H-isoindole 
• 50727-06-5 5-hydroxy-isoindole-1,3-dione 

Downstream Products

• 1020065-78-4 (2,4-bis-benzyloxy-5-isopropyl-phenyl)-(5-hydroxy-1,3-dihydro-isoindol-2-yl)-methanone 
• 1240325-36-3 (2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-hydroxy-1,3-dihydroisoindol-2-yl)methanone 
• 437650-82-3 methanesulfonic acid 2-[2-(4-tert-butoxycarbonylamino-cyclohexyl)-ethyl]-2,3-dihydro-1H-isoindol-5-yl ester 
• 437651-10-0 {4-[2-(5-cyano-1,3-dihydro-isoindol-2-yl)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester 
• 437652-01-2 methanesulfonic acid 2-[2-(4-amino-cyclohexyl)-ethyl]-2,3-dihydro-1H-isoindol-5-yl ester 
• 437652-04-5 2-[2-(4-amino-cyclohexyl)-ethyl]-2,3-dihydro-1H-isoindole-5-carbonitrile 
• 263888-56-8 tert-butyl 5-cyanoisoindoline-2-carboxylate 
• 263888-60-4 5-methanesulfonyloxy-2,3-dihydro-1H-isoindole 
• 263888-58-0 5-cyano-2,3-dihydro-1H-isoindole 
• 226070-47-9 tert-butyl 5-hydroxyisoindoline-2-carboxylate 

Relevant academic research and scientific papers

INDAZOLAMIDE DERIVATIVES

Novel indazole derivatives of the formula (I), in which R1-R3 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor

Starting from the tetrahydroisoquinoline SB-2770111, a novel series of 5-substituted-2,3-dihydro-1H-isoindoles has been designed. Subsequent optimisation resulted in identification of 19. which has high affinity for the dopamine D3 receptor (pKi 8.3) and ≥ 100-fold selectivity over other aminergic receptors. In rat studies 19 was brain penetrant with an excellent pharmacokinetic profile (oral bioavailability 77%. t1/2 5.2h).