5456-01-9

Usage

Chemical structure

1-[(E)-phenylmethylidene]aminopropan-2-ol

Type of compound

Synthetic

Effects

Stimulant on the central nervous system

Relation to other compounds

Chemically related to adrenaline

Uses

Recreational drug, prescription medication for ADHD and narcolepsy

Mechanism of action

Increases levels of dopamine and norepinephrine in the brain

Benefits

Improves focus, alertness, and mood

Potential risks

High potential for abuse and dependence, harmful effects on heart and blood vessels, addiction, and withdrawal symptoms

Regulation

Use should be carefully monitored and regulated by healthcare professionals

Upstream product

• 100-52-7 benzaldehyde 
• 78-96-6 3-amino-2-propanol 
• 17067-54-8 2-((trimethylsilyl)oxy)propan-1-amine 
• 100-46-9 benzylamine 

Downstream Products

• 111761-79-6 cis-1-(hydroxypropyl)-3-phenoxy-4-phenylazetidin-2-one 
• 27159-32-6 3-benzylaminopropan-2-ol 
• 510713-38-9 3-hydroxy-1-(2-hydroxypropyl)-4-(4-methylbenzoyl)-5-phenyl-1,5-dihydropyrrol-2-one 
• 1447254-38-7 N-{2-[(trimethylsilyl)oxy]propyl}benzimidoyl cyanide 

Relevant academic research and scientific papers

Regiochemical switching of Mitsunobu cyclisation mode of vicinal diamines with pendant hydroxyl group

Ambident 1,2-diamines derived from the nitro-Mannich reaction containing both a tosyl amide and a secondary amine could be regioselectively cyclised through the tosyl amide onto a pendant primary hydroxyl group to give piperazine (60-75% yields) or 1,4-di

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

Heterogeneous copper-catalyzed coupling of amines: a possible way for the preparation of imines

Copper(II) on 4-? molecular sieves is an efficient catalyst for the preparation of imines from benzylamines under simple reaction conditions. No oxidative atmosphere or oxidizing agents are required. Preparative experiments showed that no aldehyde intermediate can be detected even under ambient atmospheric conditions. Graphical abstract: [Figure not available: see fulltext.]

Synthesis of iminonitriles by oxone/tbab-mediated one-pot oxidative three-component strecker reaction

Oxidative three-component reaction of aldehydes, amines, and TMSCN in a biphasic solvent system (toluene/H2O) containing Oxone, tetra-n-butylammonium bromide (TBAB) and sodium bicarbonate afforded α-iminonitriles in good to excellent yields. This oxidative Strecker reaction was applicable to a wide range of aldehydes and amines, aromatic or aliphatic, of different electronic and steric properties. Substituted 1-aza-2-cyano-1,3-dienes were also accessible using α,β-unsaturated aldehydes as inputs.

A reusable zirconium(IV) Schiff base complex catalyzes highly efficient synthesis of quinoxalines under mild conditions

A zirconium(IV) complex of a bidentate Schiff base (ZrL2Cl 2) has been synthesized by the reaction of (z)-N-benzylidene-2- hydroxypropane-1-amine (HL) and ZrCl4. Spectroscopic data and elemental analyses are consistent with a monomeric complex with a ligand:Zr ratio of 2:1. The catalytic activity of ZrL2Cl2 has been investigated for the efficient synthesis of a wide variety of quinoxaline derivatives under mild conditions. The employment of ethanol as an environmentally benign solvent in this high yield method, along with high turnover numbers and reusability of the catalyst providing ready scalability, makes it appropriate for practical applications.

Synthesis and biological studies of some novel 2-substituted-3- dichloroacetyl-1,3-oxazolidines

A series of new 2-substituted-3-dichloroacetyl-1,3-oxazolidines was synthesized by the cycloaddition of amino alcohol and aldehyde or ketone, then acylation with dichloroacetyl chloride. All the compounds were characterized by IR, 1H NMR,

Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1 H -pyrrol-2(5 H)-one analogues as inhibitors of the annexin A2′S100A10 protein interaction

S100 proteins are small adaptors that regulate the activity of partner proteins by virtue of direct protein interactions. Here, we describe the first small molecule blockers of the interaction between S100A10 and annexin A2. Molecular docking yielded cand

SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS

Compounds of Formula (I): Chemical formula should be inserted here as it appears on the abstract in paper form. or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.