54563-69-8Relevant academic research and scientific papers
Steric crowding makes challenging Csp3 - F reductive eliminations feasible
Zhao, Shu-Bin,Becker, Jennifer J.,Gagne, Michel R.
scheme or table, p. 3926 - 3929 (2011/10/03)
A high-yielding fluorination of (triphos)Pt-R+ has been achieved using an array of F+ sources, with XeF2 yielding R-F in minutes. The C-F coupling proved to be a stereoretentive process that proceeds via a concerted reductive elimination from a putative dicationic Pt(IV) center. The larger the steric congestion of the (triphos)Pt-Csp3+ complexes, the more efficient the fluorination, seemingly a result of sterically accelerated C-F reductive elimination along with simultaneous deceleration of its competing processes (β-H elimination).
