54588-96-4

Upstream product

• 35714-20-6 4-benzylbenzyl alcohol 
• 623-24-5 1,4-bis(bromomethyl)benzene 
• 98-80-6 phenylboronic acid 
• 32752-54-8 4-(bromomethyl)benzophenone 
• 50-00-0 formaldehyd 
• 101-81-5 Diphenylmethane 
• 1027413-28-0 2-(4-Benzyl-benzyloxy)-tetrahydro-pyran 
• 100-39-0 benzyl bromide 
• 17100-68-4 2-((4-bromobenzyl)oxy)tetrahydro-2H-pyran 

Downstream Products

• 1025981-79-6 2-[2-(4-Benzyl-benzyl)-benzyloxy]-tetrahydro-pyran 
• 582311-57-7 (4-benzyl-benzyl)-phosphinic acid 
• 208042-69-7 3-benzyl-1-cyanomethylbenzene 
• 101096-72-4 4-benzyl-1-cyanomethylbenzene 
• 67205-99-6 4-(4-benzylbenzyl)heptane-3,5-dione 
• 202975-47-1 2-[(4-benzylbenzyl)methoxyphosphinoylmethyl]-4-methylpentanoic acid benzyl ester 
• 1027084-12-3 2-(2-{2-[2-(4-Benzyl-benzyl)-benzyl]-benzyl}-benzyloxy)-tetrahydro-pyran 
• 1026888-82-3 2-{2-[2-(4-Benzyl-benzyl)-benzyl]-benzyloxy}-tetrahydro-pyran 
• 148320-01-8 2-(2-<2-(4-Benzylbenzyl)benzyl>benzyl)benzyl alcohol 
• 148320-00-7 2-<2-(4-Benzylbenzyl)benzyl>benzyl bromide 
• 148319-99-7 2-<2-(4-Benzylbenzyl)benzyl>benzyl alcohol 
• 148319-98-6 2-(4-Benzylbenzyl)benzyl bromide 

Relevant academic research and scientific papers

Microwave-promoted palladium catalysed Suzuki cross-coupling reactions of benzyl halides with arylboronic acid

Simple catalytic systems for the coupling of benzyl halides with phenylboronic acid under microwave conditions were tested. Microwave-promoted Suzuki reaction of arylboronic acid with benzyl halides catalysed by PdCl2(PPh3)2 in the mixed solvents DMF/H2O is reported to give diaryl methane derivatives in good to high yield.

Nitrenium Salts in Lewis Acid Catalysis

Molecular compounds featuring nitrogen atoms are typically regarded as Lewis bases and are extensively employed as donor ligands in coordination chemistry or as nucleophiles in organic chemistry. By contrast, electrophilic nitrogen-containing compounds are much rarer. Nitrenium cations are a new family of nitrogen-based Lewis acids, the reactivity of which remains largely unexplored. In this work, nitrenium ions are explored as catalysts in five organic transformations. These reactions are the first examples of Lewis acid catalysis employing nitrogen as the site of substrate activation. Moreover, these compounds are readily accessed from commercially available reagents and exhibit remarkable stability toward moisture, allowing for benchtop transformations without the need to pretreat solvents.

Method for preparing coupling arene from aryl halide by ionizing, discharging and coupling

The invention discloses a method for preparing coupling arene from aryl halide by ionizing, discharging and coupling. The method comprises the following steps: placing a magnetic stirrer into a three-necked flask and adding aryl halide occupying 1/2 flask, thereby finishing the assembling of an ionizing reaction device; placing the ionizing reaction device into an oil bath pan, introducing inert gas into a reaction system, removing air from the reaction system, starting stirring and heating in the oil bath pan to make aryl halide flow back, and meanwhile, introducing water into a ball-shaped condensation pipe for cooling; starting a high-voltage power generator, and introducing powerful arc generated into the three-necked flask through a metal electrode, thereby ionizing and decomposing aryl halide steam and generating a coupling arene compound; stopping ionizing and heating when solids are separated or the backflow of aryl halide is slowed in a round-bottom flask, and then ending the reaction; recrystallizing or performing reduced pressure distillation purification on the coupling arene product in the flask, thereby acquiring the coupling arene product. The method disclosed by the invention has the advantages of low cost, high efficiency, environmental protection, and the like.

Phenyl acetamides as sPLA2 inhibitors

A class of novel phenyl acetamides is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock.

PHOSPHINATE BASED INHIBITORS OF MATRIX METALLOPROTEASES

A compound of the formula wherein R1, R2, R3, R4, R5, R6 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, synergy with cytotoxic anticancer agents, tissue ulceration, macular dege

Phosphinate based inhibitors of matrix metalloproteases

A compound of the formula wherein R1, R2, R3, R4, R5, R6 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, synergy with cytotoxic anticancer agents, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, in combination with standard NSAID'S and analgesics and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinim, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.

Biscyclophanes. Part 2: Regioselectivity in the Acid-catalysed Cycloalkylation of Benzylbenzylic Alcohol (BBA)

o-Benzylbenzylic alcohols (o-BBAs), in which the terminnal benzyl alcohol is substituted by repeating benzyl chains all in the ortho sense, have been found to have conspicuous regioselectivity in acid-catalysed cycloalkylation, giving rise to various cycl

Aromatic diketones

Beta-diketones substituted by an aryl-aliphatic group in which the aliphatic chain is interrupted by a cyclic group, and useful as anti-viral agents, are prepared by interacting the appropriate aryl-aliphatic halide with an alkali metal salt of a beta-dik