54593-26-9

Usage

Chemical Properties

Off-white solid

InChI:InChI=1/C6H7NO2/c1-4-6(3-8)5(2)9-7-4/h3H,1-2H3

Upstream product

• 201008-69-7 3,5-dimethyl-4-(1,3-dithian-2-yl)-isoxazole 
• 123-54-6 acetylacetone 
• 2510-36-3 3,5-dimethyl-4-isoxazolecarboxylic acid 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 56328-87-1 methyl 3,5-dimethylisoxazole-4-carboxylate 
• 55727-23-6 3‐(1,3-dithiane-2-yl)pentane-2,4-dione 
• 100596-16-5 3-(1,3-dithian-2-yl)-pentane-2,4-dione 
• 19788-36-4 4-hydroxymethyl-3,5-dimethylisoxazole 

Downstream Products

• 110773-98-3 vinyl(3,5-dimethyl4-isoxazolyl)carbinol 
• 39511-14-3 (3,5-dimethyl-isoxazol-4-yl)-phenyl-methanol 
• 87967-96-2 NSC 375973 
• 653579-56-7 1-(3,5-Dimethyl-isoxazol-4-yl)-propenone 
• 110774-00-0 2-(5-bicyclo<2.2.1>hepten-2-ylcarbonyl)-2-acetyl-3-methyl-2H-azirine 
• 31301-47-0 (3,5-dimethylisoxazol-4-yl)(phenyl)methanone 
• 127916-10-3 1-(3,5-Dimethyl-isoxazol-4-yl)-1-phenyl-ethane-1,2-diol 
• 19788-36-4 4-hydroxymethyl-3,5-dimethylisoxazole 
• 1421838-38-1 methyl 2-(4-(2-(3,5-dimethylisoxazol-4-yl)-2-hydroxyethoxy)phenyl)acetate 
• 1421838-41-6 2-(4-(2-(3,5-dimethylisoxazol-4-yl)-2-oxoethoxy)phenyl)-N-((2,4-dimethylphenyl)(phenyl)methyl)acetamide 
• 1421837-32-2 C₃₀H₃₂N₂O₄ 
• 1421838-42-7 methyl 2-(1-(3,5-dimethylisoxazol-4-yl)-2-(4-(2-(((2,4-dimethylphenyl)(phenyl)methyl)amino)-2-oxoethyl)phenoxy)ethoxy)-2-methylpropanoate 
• 1421837-91-3 C₃₄H₃₈N₂O₆ 
• 35166-20-2 1-(3,5-dimethyl-1,2-oxazol-4-yl)ethanone 

Relevant academic research and scientific papers

Method for synthesizing aromatic aldehyde through iron catalyzed oxidation allyl aromatic compound

The invention discloses a method for synthesizing aromatic aldehyde through an iron catalyzed oxidation allyl aromatic compound. According to the specific method, under the promotion effect of hydrogen silane, with air or oxygen as the oxidant, the aromatic aldehyde compound is synthesized through the iron catalyzed oxidation allyl aromatic compound, the reaction temperature is 20-150 DEG C, and the time is 0.25-60 h. The method has the advantages that a catalyst source is wide, the price is low and the environment is protected; an oxidant source is wide, the price is low and no waste is generated; the reaction conditions are mild, selectivity is high and the yield is high; a substrate source is wide and stable; a substrate functional group is high in compatibility and a substrate is widein application range; complicated small molecules are compatible and can be well converted into aldehyde. The target product separation yield can reach up to 96% under the optimized reaction conditions.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-reiated orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORy.

COMPOUNDS AND METHODS

The present invention relates to no vel retinoid-related orphan receptor gamma (RQRy) modulators and their use in the treatment of diseases mediated by RORy.

BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which bears a substituent represented by the general formula: R-Z1-X-Z2- (wherein R1 is hydrogen or optionally substituted hydrocarbyl; X is optionally substituted alkylene; and Z1 and Z2 are each a heteroatom) and may be further substituted, with R being optionally bonded to the aromatic ring to form another ring; Y is optionally substituted imino; and R2 and R3 are each optionally substituted aliphatic hydrocarbyl or an optionally substituted hetero-alicyclic group.

Dehydroamino acids

Compounds of formula 1 and 1-1, wherein R1 is hydrogen, hydroxy, amino or halogen, R2 is hydrogen, hydroxy, or halogen and R3 is hydrogen (Formula 1) or R1 is hydrogen and R2 and R3 taken together with the ethenylene group connecting them form phenyl, pyrrole, pyrroline, oxopyrroline, pyrazole, triazole, or imidazole (Formula 1-1), A is R4 R5 are hydrogen, methyl, ethyl or halogen except that R4 r5 cannot both be hydrogen; and 1) B is hydrogen, or lower alkyl; or 2) B is where R6 R7 R8 and R9 are independently hydrogen, hydroxy, aminosulfonyl, halogen, lower alkoxy, cyano, amino, lower alkyl, lower alkyl amino, or nitro; or 3) B is where R10 is hydrogen, hydroxy, halogen, or lower alkyl and C is a five- or six- membered ring with 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur, which ring may be unsubstituted or mono- or di- substituted with lower alkyl, cycloalkyl, amino, or substituted amino; 4) B is where X and Y are independently methylene or nitrogen; or 5) B is where at leat one of T, U, V, or W is nitrogen, and any of T, U, V or W which is carbon may be substituted with lower alkyl, lower alkyl amino, lower alkoxy, hydroxy, aminosulfonyl, halogen, cyano, amino, or nitro; or 6) B is where Y is carbon or nitrogen; or 7) B is a five-membered aromatic ring with 1 to 3 heteratoms selected from nitrogen, oxygen, and sulfur which ring may be unsubstituted or mono- or di-substituted with lower alkyl, cycloalky, trifluoroloweralkyl, amino, halogen, substituted amino, or which ring may be fused with a 5 or 6 membered aromatic ring containing 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur; and pharmaceutically acceptable salts thereof, and related prodrugs, pharmaceutical compositions and methods of treatment, which compounds are useful for treating psoriasis.

Routes to building blocks for heterocyclic synthesis by reduction of ketene dithioacetals

Two general methods have been developed permitting the effective reduction of ketene dithioacetals to give substituted dithianes. Reduction with magnesium in methanol is less reliable than reduction with zinc in acetic acid. The greater inconsistency of magnesium in methanol has been investigated by a cyclic voltammetric study of the substrates. The utility of the dithianes has been successfully illustrated by cyclisations to afford, after deprotection, a variety of heterocyclic aldehydes.

NEUTRAL DICHROMATE OXIDATION. PREPARATION AND UTILITY OF ISOXAZOLE ALDEHYDES

Isoxazole alcohols 1 can be oxidized by potassium dichromate in neutral organic media to give the corresponding aldehydes, 2 without destruction of the isoxazole ring.Isoxazole aldehydes 2 are of utility as starting materials for 4-(4'-isoxazyl)-1,4-dihydropyridines 3.