39511-14-3

Upstream product

• 93548-06-2 4-(chloro-phenyl-methyl)-3,5-dimethyl-isoxazole 
• 54593-26-9 3,5-dimethyl-1,2-oxazole-4-carbaldehyde 
• 100-52-7 benzaldehyde 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 31301-45-8 3,5-dimethylisoxazole-4-carbonyl chloride 
• 2510-36-3 3,5-dimethyl-4-isoxazolecarboxylic acid 
• 31301-47-0 (3,5-dimethylisoxazol-4-yl)(phenyl)methanone 

Downstream Products

• 31301-47-0 (3,5-dimethylisoxazol-4-yl)(phenyl)methanone 
• 93548-06-2 4-(chloro-phenyl-methyl)-3,5-dimethyl-isoxazole 
• 127916-10-3 1-(3,5-Dimethyl-isoxazol-4-yl)-1-phenyl-ethane-1,2-diol 

Relevant academic research and scientific papers

Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: A novel class of potent enterovirus inhibitors

A series of pyrazolo[3,4-d]pyrimidines were synthesized and their antiviral activity was evaluated in a plaque reduction assay. It is very interesting that this class of compounds provide remarkable evidence that they are very specific for human enteroviruses, in particular, coxsackieviruses. Some derivatives proved to be highly effective in inhibiting enterovirus replication at nanomolar concentrations. SAR studies revealed that the phenyl group at the N-1 position and the hydrophobic diarylmethyl group at the piperazine largely influenced the in vitro antienteroviral activity of this new class of potent antiviral agents. It was found that the pyrazolo[3,4-d]pyrimidines with a thiophene substituent, such as compounds 20-24, in general exhibited high activity against coxsackievirus B3 (IC50=0.063-0.089μM) and moderate activity against enterovirus 71 (IC50=0.32-0.65μM) with no apparent cytotoxic effect toward RD (rhabdomyosarcoma) cell lines (CC5025μ M).

Photochemistry of 4-Acylisoxazoles

The photochemistry of 4-acylisoxazoles 4, 5, 13, 14, and 17 was investigated in an effort to clarify literature contradictions and anomalies and to provide a more detailed picture of the nature and number of intermediates involved in photoreactions of these systems.In contrast to a previous report on the photorearrangement of 14, both oxazoles expected from a 2H-azirine intermediate have been observed.Wavelength studies of 5 and the derived 2H-azirine 10 revealed evidence for the involvement of at least two distinct product-forming intermediates.The results of quantum yield and laser photolysis measurements for ketones 4, 14, and 17 have been interpreted in terms of rapid openings of triplet states to form diradical-like intermediates coupled with efficient reclosures (70-99percent).