5460-45-7

Basic information

• Product Name: 2-ethylhexyl formate
• Synonyms: 2-ethylhexyl formate;Formic acid 2-ethylhexyl ester;Nsc21825
• CAS NO: 5460-45-7
• Molecular Formula: C₉H₁₈O₂
• Molecular Weight: 158.23802
• EINECS: 226-740-6
• Mol File: 5460-45-7.mol

Chemical Properties

• Melting Point: -39.1°C (estimate)
• Boiling Point: 183.34°C (estimate)
• Flash Point: 71.8°C
• Appearance: /
• Density: 0.8809 (estimate)
• Vapor Pressure: 0.409mmHg at 25°C
• Refractive Index: 1.4040 (estimate)
• CAS DataBase Reference: 2-ethylhexyl formate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethylhexyl formate(5460-45-7)
• EPA Substance Registry System: 2-ethylhexyl formate(5460-45-7)

Safety Data

• Hazardous Substances Data: 5460-45-7(Hazardous Substances Data)

Usage

Uses

Used in Flavoring Industry:
2-Ethylhexyl formate is used as a flavoring agent for its distinctive fruity scent, enhancing the taste and aroma of various food products.
Used in Chemical Production:
2-Ethylhexyl formate serves as a solvent and intermediate in the production of different chemicals, contributing to the synthesis of a wide range of compounds.
Used in Solvent Applications:
As a solvent, 2-Ethylhexyl formate is utilized in various industrial processes, aiding in the dissolution and handling of other substances for manufacturing purposes.
Safety Note:
Due to its flammable nature, 2-Ethylhexyl formate should be handled with care and proper safety measures should be followed to minimize the risk of exposure and adverse effects.

InChI:InChI=1/C9H18O2/c1-3-5-6-9(4-2)7-11-8-10/h8-9H,3-7H2,1-2H3

Upstream product

• 64-18-6 formic acid 
• 104-76-7 2-Ethylhexyl alcohol 
• 123-05-7 d,l-2-ethylhexanal 
• 109-94-4 formic acid ethyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 56136-01-7 tri-2-ethylhexyl orthoformate 
• 25234-36-0 2-decyltetradec-2-enal 
• 98-88-4 benzoyl chloride 
• 100528-70-9 2-(2-ethylhexyloxy)-tetrahydro-2H-pyran 
• 100011-12-9 N-((2-ethylhexyloxy)methylidene) dimethyliminium chloride 

Relevant articles and documents

ETHERIFICATION PROCESS

The present invention relates to a process for preparing ethers, particularly unsymmetrical ethers, and preferably ethers suitable for use as base stocks for lubricant compositions. In particular, the process involves the reaction of an α,β-unsaturated aldehyde with a trihydrocarbyl orthoester to form an α,β-unsaturated acetal and conversion of the α,β- unsaturated acetal to an ether through hydrogenation and hydrogenolysis.

METHOD OF CONVERTING ALCOHOL TO HALIDE

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

Formamides as Lewis Base Catalysts in SNReactions—Efficient Transformation of Alcohols into Chlorides, Amines, and Ethers

A simple formamide catalyst facilitates the efficient transformation of alcohols into alkyl chlorides with benzoyl chloride as the sole reagent. These nucleophilic substitutions proceed through iminium-activated alcohols as intermediates. The novel method, which can be even performed under solvent-free conditions, is distinguished by an excellent functional group tolerance, scalability (>100 g) and waste-balance (E-factor down to 2). Chiral substrates are converted with excellent levels of stereochemical inversion (99 %→≥95 % ee). In a practical one-pot procedure, the primary formed chlorides can be further transformed into amines, azides, ethers, sulfides, and nitriles. The value of the method was demonstrated in straightforward syntheses of the drugs rac-Clopidogrel and S-Fendiline.

Highly efficient formylation of alcohols, thiols and aniline derivatives by a heterogeneous (HCOOH/SiO2) system under microwave irradiation and solvent-free conditions

A simple, rapid and efficient microwave-assisted procedure for the formylation of aniline derivatives and alcohols, using a heterogeneous (HCOOH/SiO2) system under solvent-free conditions is reported. The method is applied to a set of amines, alcohols and thiols and short reaction times (10 min) with high yields are reported. This protocol introduces a practical and viable green technology of solvent-free and catalyst-free reactions.

Efficient one-step conversion of tetrahydropyranyl ethers into acetates and formates in the presence of potassium dodecatungstocobaltate K 5CoW12O40·3H2O

Tetrahydropyranyl ethers derived from primary alcohols were directly and efficiently converted into the corresponding acetates and formates by the action of ethyl acetate, acetic acid, acetic anhydride, and ethyl formate in the presence of a catalytic amount of potassium dodecatungstocobaltate K 5CoW12O40 ? 3H2O. Tetrahydropyranyl ethers derived from secondary alcohols and phenols can also be transformed into the corresponding acetates with the use of acetic anhydride, but K5CoW12O40 ? 3H2O was ineffective for esterification with ethyl acetate, acetic acid, and ethyl formate.

Cerium polyoxometalate as a reusable catalyst for acetylation and formylation of alcohols

Efficient esterification of primary and sterically-hindered secondary or tertiary alcohols with acetic anhydride was achieved in the presence of ammonium decatungestocerate(IV) icosahydrate, (NH4)8[CeW 10O36]·OH2O, as catalyst in high yields. Primary and secondary alcohols were also converted to their corresponding acetates and formates with acetic acid and ethyl formate in the presence of this catalyst. Easy work-up, non-toxicity, reusability, and stability of the catalyst are noteworthy advantages of this method. Springer-Verlag 2004.

Novel catalytic acetylation and formylation of alcohols with potassium dodecatungstocobaltate trihydrate (K5CoW12O40·3H2O)

Acetylation and formylation reactions of alcohols with ethyl acetate, acetic acid and ethyl formate were catalyzed with potassium dodecatungstocobaltate trihydrate (K5CoW12O40·3H2O) in a mild, efficient and convenient method with high to excellent yields.

THE RUTHENIUM COMPLEX-CATALYZED REDUCTION OF KETONES BY FORMIC ACID

An equimolar mixture of a ketone and formic acid was heated without solvent at 125 degC for 3 h in the presence of catalytic amount of dichlorotris(triphenylphosphine)ruthenium(II) to give the corresponding secondary alcohols in excellent yields.