5462-03-3

Upstream product

• 2658-24-4 2,2-dimethylaziridine 
• 62-53-3 aniline 
• 2322-45-4 2-bromo-2-methyl-N-phenylpropanamide 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 122884-27-9 2,4,4-trimethyl-1-phenyl-4,5-dihydro-1H-imidazole 
• 64038-71-7 4,4-dimethyl-1-phenyl-imidazolidine 
• 71620-94-5 3,3,5,5-tetramethyl-1-phenylpiperazin-2-one 
• 72610-25-4 3,3,6,6-Tetramethyl-4-phenyl-piperazin-2-one 

Relevant academic research and scientific papers

Pd-Catalyzed C-H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones

A palladium mediated C-H aziridination reaction of 3,3,5,5-substituted-piperazin-2-ones has been developed using phenyliodonium diacetate (PIDA) and succinic acid to give synthetically useful bicyclic aziridines, in moderate to good yields. Succinic acid

Copper-Catalyzed Amination of Congested and Functionalized α-Bromocarboxamides with either Amines or Ammonia at Room Temperature

There are several reports on the synthesis of alkylamines, but most of the reported methods are not suitable for the synthesis of hindered amines. In this research, we found that a copper catalyst is effective for the formation of congested C?N bonds at room temperature. Control experiments revealed that a copper amide is a key intermediate. Moreover, when a chiral amine was used, a quaternary carbon stereogenic center was created with good selectivity.

Selective alkylation of (Hetero)aromatic amines with alcohols catalyzed by a ruthenium pincer complex

A readily available pincer ruthenium(II) complex catalyzes the selective monoalkylation of (hetero)aromatic amines with a wide range of primary alcohols (including pyridine-, furan-, and thiophene-substituted alcohols) with high efficiency when used in low catalyst loadings (1 mol %). Tertiary amine formation via polyalkylation does not occur, making this ruthenium system an excellent catalyst for the synthesis of sec-amines.