71620-94-5Relevant academic research and scientific papers
Synthesis of electron-deficient N1-(Hetero)aryl 3,3,5,5-tetramethyl piperazinones
Alanine, Thomas A.,Stokes, Stephen,Scott, James S.
, p. 357 - 361 (2017)
An alternative synthesis of N1-(hetero)aryl 3,3,5,5-tetra-substituted piperazin-2-ones is demonstrated using a copper-mediated Goldberg arylation of a common intermediate in good to fair yields. An improved synthesis of 3,3,5,5-tetramethyl piperazin-2-one is also described. This method allows for the synthesis of substituted piperazin-2-ones which are challenging or inaccessible using traditional Bargellini chemistry.
Pd-Catalyzed C-H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones
Alanine, Thomas A.,Stokes, Stephen,Roberts, Craig A.,Scott, James. S.
supporting information, p. 53 - 56 (2017/12/27)
A palladium mediated C-H aziridination reaction of 3,3,5,5-substituted-piperazin-2-ones has been developed using phenyliodonium diacetate (PIDA) and succinic acid to give synthetically useful bicyclic aziridines, in moderate to good yields. Succinic acid
Palladium-catalyzed enantioselective C-H activation of aliphatic amines using chiral anionic BINOL-phosphoric acid ligands
Smalley, Adam P.,Cuthbertson, James D.,Gaunt, Matthew J.
supporting information, p. 1412 - 1415 (2017/02/10)
The design of an enantioselective Pd(II)-catalyzed C-H amination reaction is described. The use of a chiral BINOL phosphoric acid ligand enables the conversion of readily available amines into synthetically valuable aziridines in high enantiomeric ratios.
Hindered Amines. Novel Synthesis of 1,3,3,5,5-Pentasubstituted 2-Piperazinones
Lai, John T.
, p. 754 - 755 (2007/10/02)
1,3,3,5,5-Pentasubstituted 2-piperazinones (2) are prepared from easily available N1,2,2-trisubstituted 1,2-ethanediamine (1), chloroform, and ketones in phase transfer catalyzed reactions and probably not through the dichlorocarbene intermedia
