54639-27-9Relevant articles and documents
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Baker,Stanonis
, p. 699,701 (1951)
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Synthesis of enantiopure (S)-α-hydroxy carboxanilides from (S)-α-amino acids
Girreser,Noe
, p. 1223 - 1224 (2007/10/02)
α-Hydroxy carboxanilides 3 a-c were obtained without racemization in a synthetically simple way starting from the corresponding α-amino acids by diazotization and subsequent treatment of the sodium α-hydroxy carboxylates with anilinium chloride in moderate yields. The enantiopurity of 3a-c was easily determined by 1H NMR spectroscopy of the diastereomeric O,O-acetals 5/6a-c derived from exo-lactol 4.