54640-02-7

Usage

Uses

Used in Pharmaceutical Industry:
Methyl-(4-aminomethyl)cyclohexane carboxylate hydrochloride salt 95% is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form essential molecular structures. Its unique functional groups contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl-(4-aminomethyl)cyclohexane carboxylate hydrochloride salt 95% is utilized as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties allow for the creation of effective compounds that protect crops and enhance agricultural productivity.
Used in Organic Compounds Synthesis:
Methyl-(4-aminomethyl)cyclohexane carboxylate hydrochloride salt 95% is employed as a versatile building block in the synthesis of various organic compounds. Its functional groups enable the formation of diverse molecular structures, broadening its applicability in organic chemistry and contributing to the development of new materials and compounds with specific properties.

Upstream product

• 1197-17-7 4-aminomethyl-cyclohexanecarboxylic acid 
• 77-76-9 2,2-dimethoxy-propane 
• 1634-04-4 tert-butyl methyl ether 
• 67-56-1 methanol 

Relevant academic research and scientific papers

XANTHINE DERIVATIVES AND USES THEREOF AS INHIBITORS OF BROMODOMAINS OF BET PROTEINS

The present invention relates to a compound having the following formula (I): (I) wherein: - R is a (C1-C6)alkyl group;- R'' is preferably H;- Ar is a (C5-C12)arylene radical;- X1 is -C(=O)- or -SO2-; and- R' is chosen from the group consisting of possibly substituted (C1-C6)alkyl, heteroaryl, (C5-C12)aryl, and (hetero)cycloalkyl groups, or a pharmaceutically acceptable salt and/or tautomeric form thereof, or its racemates, diastereomers or enantiomers.

Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

Process development and scale-up for the preparation of the 1-methyl-quinazoline-2,4-dione wnt inhibitor SEN461

A practical and scalable route to the Wnt inhibitor SEN461 1 is described herein. The optimized route consists of nine chemical steps. The intermediates are solids and were isolated by filtrations. Critical reactions steps in the medicinal chemistry route were modified for an initial scale-up process, and as a result, we developed a synthetic procedure for the preparation of multihundred gram quantities of the final product. A further process development for the phase 1 clinical batch campaign is reported.

A convenient synthesis of amino acid methyl esters

A series of amino acid methyl ester hydrochlorides were prepared in good to excellent yields by the room temperature reaction of amino acids with methanol in the presence of trimethylchlorosilane. This method is not only compatible with natural amino acids, but also with other aromatic and aliphatic amino acids.