54656-03-0

Upstream product

• 1530-38-7 ((4-methoxyphenyl)methyl)triphenylphosphonium bromide 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 123-11-5 4-methoxy-benzaldehyde 
• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 54656-02-9 3-chloro-1,2,3-tris-(4-methoxy-phenyl)-propan-1-one 

Relevant academic research and scientific papers

Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents

To develop novel anti-inflammatory agents with improved pharmaceutical profiles, twenty-eight novel sesquistilbene indanone analogues were synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. Among these compounds, compound 11k was found to be one of the most potent analogues in inhibiting NO production in LPS-stimulated RAW264.7 cells. Furthermore, it could also significantly suppress LPS-induced iNOS and COX-2 expression and NO production through TLR4/JNK/NF-κB signaling pathway in a concentration dependent manner.