5466-27-3

Basic information

• Product Name: 4-ethoxycarbonyl-2-quinolone
• Synonyms: 4-ethoxycarbonyl-2-quinolone;4-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester;Ethyl 2-hydroxyquinoline-4-carboxylate;2-Hydroxy-quinoline-4-carboxylic acid ethyl ester;2-keto-1H-quinoline-4-carboxylic acid ethyl ester;2-oxo-1H-quinoline-4-carboxylic acid ethyl ester;4-Quinolinecarboxylic acid, 2-hydroxy-, ethyl ester;Ethyl 1,2-dihydro-2-oxoquinoline-4-carboxylate
• CAS NO: 5466-27-3
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.22
• Mol File: 5466-27-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 421°C at 760 mmHg
• Flash Point: 208.4°C
• Appearance: /
• Density: 1.246g/cm³
• Vapor Pressure: 2.7E-07mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 4-ethoxycarbonyl-2-quinolone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethoxycarbonyl-2-quinolone(5466-27-3)
• EPA Substance Registry System: 4-ethoxycarbonyl-2-quinolone(5466-27-3)

Safety Data

• Hazardous Substances Data: 5466-27-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H11NO3/c1-2-16-12(15)9-7-11(14)13-10-6-4-3-5-8(9)10/h3-7H,2H2,1H3,(H,13,14)

Upstream product

• 15733-89-8 2-hydroxyquinoline-4-carboxylic acid 
• 5471-39-6 2-ethoxy-quinoline-4-carboxylic acid ethyl ester 
• 64-17-5 ethanol 
• 91-56-5 indole-2,3-dione 
• 574-17-4 1-acetyl-1H-indole-2,3-dione 
• 75-03-6 ethyl iodide 
• 141-82-2 malonic acid 

Downstream Products

• 1315336-95-8 ethyl 2-(tosyloxy)quinoline-4-carboxylate 
• 1315337-07-5 ethyl 2-(perfluorophenyl)quinoline-4-carboxylate 
• 90097-49-7 4-hydroxymethyl-3,4-dihydro-1H-quinolin-2-one 
• 67752-52-7 ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate 
• 19343-78-3 4-methyl-1,2,3,4-tetrahydroquinoline 
• 41874-24-2 2-hydroxy-quinoline-4-carboxylic acid hydrazide 

Relevant articles and documents

Microwave-assisted synthesis of quinoline derivatives from isatin

Microwave irradiation has been used for a rapid and efficient synthesis of quinoline-4-carboxylic acids 5a-g and 1,2,3,4-tetrahydroacridine-9-carboxylic acid (6) from the reaction of isatins 1-3 with acyclic and cyclic ketones in basic medium. 2-Hydroxyquinoline-4-carboxylic acid (11) was also obtained by irradiating a mixture of isatin 1 and malonic acid in AcOH. The esters of 5f and 11 and their respective hydrazides 8 and 13 were also prepared under MWI. Copyright Taylor & Francis, Inc.