5467-31-2

Usage

Molecular Structure

The compound consists of an isoindole ring (a bicyclic structure with two carbonyl groups), a nitrophenyl group (a nitro group attached to a phenyl ring), and a propanoic acid moiety (a three-carbon chain with a carboxylic acid functional group).

Synthetic Compound

It is a man-made chemical with potential applications in various fields such as biology, pharmaceuticals, materials science, and biochemistry.

Potential Biological and Pharmaceutical Applications

Due to its complex structure and various functional groups, the compound may exhibit properties or undergo reactions that are significant for drug development and biochemistry research.

Chemical Reactivity

The presence of different functional groups (carbonyl, nitro, and carboxylic acid) in the molecule may lead to various chemical reactions, making it an interesting subject for study in materials science and biochemistry.

Physical Properties

The specific physical properties of the compound, such as solubility, melting point, and boiling point, may be of interest for its potential applications in different fields.

Stability

The compound's stability under various conditions (e.g., temperature, pH, presence of other chemicals) could be crucial for its potential use in pharmaceuticals and other applications.

Biocompatibility

If the compound is found to be biocompatible, it may have potential applications in drug delivery systems or as a component in biological research.

Toxicity

Understanding the toxicity of the compound is essential for evaluating its safety and potential applications in pharmaceuticals and other fields.

Upstream product

• 60666-01-5 (RS)-N-phthaloyl-p-nitrophenylalanine 
• 85-44-9 phthalic anhydride 
• 56613-61-7 (R)-4-nitro-phenylalanine 
• 101445-16-3 N-(2-carboxy-benzoyl)-4-nitro-phenylalanine 
• 855633-22-6 (4-nitro-benzyl)-phthalimido-malonic acid diethyl ester 
• 100-14-1 4-nitrobenzyl chloride 
• 949-99-5 4-nitro-3-phenyl-L-alanine 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 207569-25-3 p-nitro-L-phenylalanine hydrate 
• 1991-83-9 4-nitrophenylalanine 

Downstream Products

• 98722-37-3 4-nitro-N,N-phthaloyl-DL-phenylalanin-ethyl ester 
• 131175-70-7 (R)-N-phthaloyl-p-nitrophenylalanine 
• 17451-66-0 N-phthaloyl-3-(4-nitrophenyl)-(S)-alanine 

Relevant academic research and scientific papers

NOVEL TRF1 MODULATORS AND ANALOGUES THEREOF

Novel TRF1 modulators and analogues thereof. There is provided compounds of Formula I, wherein R, R1, R2 and X have meanings written in the description. Such compounds are useful as TRF1 inhibitors and, for that reason, as medicaments, in the treatment of cancer, particularly high cancer stem cell cancer like glioblastoma and lung cancer, and can be also useful for the development of additional TRF1 inhibitors and increasing knowledge about TRF1 activity.

Synthesis process of N-paraphthalyl(diethanol)amino-L-phenylalanine ethyl ester

The invention provides a synthesis process of N-paraphthalyl(diethanol)amino-L-phenylalanine ethyl ester. The process includes the first step of amino protection reaction, the second step of esterification reaction, the third step of reduction reaction and the fourth step of substitution reaction. According to the synthesis process, amino is protected by phthalic anhydride, and then esterification, reduction and substitution are conducted obtain the product. The process has the advantages of being low in cost, mild in reaction condition, low in toxicity, convenient to operate, high in yield and suitable for industrial production.

Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)-H Bonds

The transition-metal-catalyzed direct C-H bond fluorination is an attractive synthetic tool toward the preparation of organofluorines. While many methods exist for the direct sp3 C-H functionalization, site-selective fluorination of unactivated sp3 carbons remains a challenge. Direct, highly site-selective and diastereoselective fluorination of aliphatic amides via a palladium-catalyzed bidentate ligand-directed C-H bond functionalization process on unactivated sp3 carbons is reported. With this approach, a wide variety of β-fluorinated amino acid derivatives and aliphatic amides, important motifs in medicinal and agricultural chemistry, were prepared with palladium acetate as the catalyst and Selectfluor as the fluorine source.

Substituent effect on the stereoselectivity of acylation of racemic heterocyclic amines with N-phthaloyl-3-aryl-(S)-alanyl chlorides

The acylative kinetic resolution of racemic 2-methyl-1,2,3,4- tetrahydroquinoline and 2,3-dihydro-3-methyl-4H-1,4-benzoxazine using acyl chlorides of N-phthaloyl-(S)-phenylalanine, N-phthaloyl-3-(4-nitrophenyl)-(S)- alanine and N-phthaloyl-O-methyl-(S)-tyrosine as chiral resolving agents has been carried out. It is shown that the effectiveness of an acylative kinetic resolution depends on the electronic effects of substituents in the phenyl fragment of the acylating agent and increases as the electron-donating properties of the para-substituent (OMe > H > NO2) in phenyl fragment of N-phthaloyl-3-aryl-(S)-alanyl chlorides increase; conducting the process at a reduced temperature also contributes to an enhancement of the kinetic resolution.

Neighbouring group effects promote substitution reactions over elimination and provide a stereocontrolled route to chloramphenicol

In reactions of β-brominated valine and p-nitrophenylalanine derivatives to give β-hydroxy amino acid derivatives the carboxyl group, when protected as an amide, exerts a neighbouring group effect to facilitate the substitution process, and reduce competing elimination reactions. As a consequence of the effect, the (2R,3R)- and (2R,3S)-stereoisomers of 3-bromo-N-tert-butyl-N(α)-phthaloyl-p-nitrophenylalaninamide both react to give (2S,3R)-3-hydroxy-N-tert-butyl-N(α)-phthaloyl-p-nitrophenylalaninamid e, providing a stereoconvergent route to chloramphenicol.