54671-67-9Relevant academic research and scientific papers
α-Acyl-α-diazoacetates in Transition-Metal-Free β-Lactam Synthesis
Synofzik, Judith,Dar'In, Dmitry,Novikov, Mikhail S.,Kantin, Grigory,Bakulina, Olga,Krasavin, Mikhail
, p. 12101 - 12110 (2019)
Thermally promoted reaction of α-acyl-α-diazoacetates with imines has been investigated. The transformation, earlier reported predominantly under transition metal catalyzed conditions, delivers α-alkoxycarbonyl-substituted β-lactams with outstanding diastereoselectivity. DFT calculations performed in order to evaluate energetically feasible reaction pathways revealed the intermediacy of 1,3-oxazin-4-one intermediates hitherto never implicated in the Staudinger synthesis of β-lactams.
Preparation of N,N-difluoroamines
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, (2008/06/13)
N,N-difluoroamines are prepared by fluorination of compounds containing a >C=N-- bond using molecular fluorine or a hypofluorite in which the fluoroxy group is bonded to an inert electron attracting group, such hypofluorites including fluoroalkyl hypofluo
