54677-53-1

Basic information

• Product Name: 2-METHYLPYRROLIDINE HYDROCHLORIDE
• Synonyms: 2-METHYLPYRROLIDINE HYDROCHLORIDE;Pyrrolidine, 2-Methyl-, hydrochloride
• CAS NO: 54677-53-1
• Molecular Formula: C₅H₁₁N*ClH
• Molecular Weight: 121.61
• Mol File: 54677-53-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Water Solubility: Soluble in water
• CAS DataBase Reference: 2-METHYLPYRROLIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLPYRROLIDINE HYDROCHLORIDE(54677-53-1)
• EPA Substance Registry System: 2-METHYLPYRROLIDINE HYDROCHLORIDE(54677-53-1)

Safety Data

• Statements: 36/38
• Safety Statements: 26-36
• Hazardous Substances Data: 54677-53-1(Hazardous Substances Data)

Usage

General Description

2-Methylpyrrolidine hydrochloride is a chemical compound with a molecular formula of C5H11N·HCl. It is a hygroscopic, white crystalline powder that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has also been used as a chiral auxiliary in asymmetric synthesis and as a solvent for a variety of reactions. Additionally, 2-Methylpyrrolidine hydrochloride has been investigated for its potential use in the treatment of nicotine addiction due to its ability to act as a partial agonist for nicotinic acetylcholine receptors. As with any chemical compound, proper handling and storage are important to ensure safety and effectiveness for its intended applications.

Upstream product

• 157007-54-0 2-(R)-methylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 43041-12-9 methyl (2R)-pyrrolidine-2-carboxylate 
• 124-63-0 methanesulfonyl chloride 
• 338945-22-5 (S)-2-iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 132482-09-8 tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate 

Downstream Products

• 636-41-9 2-methyl-1H-pyrrole 
• 921616-75-3 1,1-dimethylethyl 4-[4-({3-[(R)-2-methyl-1-pyrrolidinyl]propyl}oxy)phenyl]-3-oxo-1-piperazinecarboxylate 
• 1260098-08-5 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-morpholin-4-yl-ethanone 
• 1260098-10-9 1-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperidine-4-carbonitrile 
• 1260098-14-3 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-(4-trifluoromethyl-piperidin-1-yl)-ethanone 
• 1260098-11-0 2-(4,4-difluoro-piperidin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-19-8 2-(3,3-difluoro-piperidin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-27-8 2-(3,3-difluoro-pyrrolidin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-30-3 2-(4-acetyl-piperazin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-31-4 2,2,2-trifluoro-1-[4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazin-1-yl]-ethanone 
• 1260098-33-6 2-(4-methanesulfonyl-piperazin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-35-8 2-(4-benzoyl-piperazin-1-yl)-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-68-7 2-[4-(4-fluoro-benzoyl)-piperazin-1-yl]-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone 
• 1260098-47-2 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-ethanone 

Relevant articles and documents

Production method of (R)-2-methylpyrrolidine hydrochloride

The invention provides a production method of (R)-2-methylpyrrolidine hydrochloride. The method is an industrial production method and adopts a reduction method of sodium borohydride and different solvents to obtain the (R)-2-methylpyrrolidine hydrochloride with the product purity of 98% or above and the product total yield of 70% or above. Also provided is a process for the synthesis of chiral (R)-2-methylpyrrolidine hydrochloride. Meanwhile, raw materials adopted in the method are easy to obtain, synthesis conditions are simple, the product yield is high, and the method is suitable for industrial production.

MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-receptor associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.

OXAZOLE DERIVATIVES AS HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES

The present invention discloses novel aryl oxazole compounds of Formula I (I), or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing and using such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. Formula I (I) or a pharmaceutically acceptable salt thereof, wherein: m is independenlly at each occurrence 1, 2, or 3, Z independently represents carbon (substituted with hydrogen or the optional substituents indicated herein) or nitrogen, provided that when Z is nitrogen then R6 is not attached to Z; R1 and R2 are independently -(C1-C7) alkyl(optionally substituted with one to three halogens), or R1 and R2 and the nitrogen to which they are attached form an azetidinyl ring, a pyrrolidinyl ring, or a piperidinyl ring, wherein further the azetidinyl, pyrrolidinyl, or piperidinyl ring so formed may be optionally substituted one to three times with R5; R6 is independently at each occurrence -H, -halogen, or -CH3.