5468-76-8

Basic information

• Product Name: 2,2-dichloro-N,N-dimethylacetamide
• Synonyms: 2,2-dichloro-N,N-dimethylacetamide;Acetamide,2,2-dichloro-N,N-dimethyl-
• CAS NO: 5468-76-8
• Molecular Formula: C₄H₇Cl₂NO
• Molecular Weight: 156.01048
• EINECS: 226-790-9
• Mol File: 5468-76-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 191°C at 760 mmHg
• Flash Point: 69.3°C
• Appearance: /
• Density: 1.277g/cm³
• Vapor Pressure: 0.527mmHg at 25°C
• Refractive Index: 1.468
• CAS DataBase Reference: 2,2-dichloro-N,N-dimethylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dichloro-N,N-dimethylacetamide(5468-76-8)
• EPA Substance Registry System: 2,2-dichloro-N,N-dimethylacetamide(5468-76-8)

Safety Data

• Hazardous Substances Data: 5468-76-8(Hazardous Substances Data)

Usage

General Description

2,2-dichloro-N,N-dimethylacetamide is a chemical compound with the molecular formula C4H7Cl2NO. It is a clear, colorless to pale yellow liquid with a strong odor. This chemical is commonly used as a solvent in various industrial processes such as in the production of pharmaceuticals, pesticides, and dyes. It is also used as a reagent in organic synthesis and as a paint remover. However, 2,2-dichloro-N,N-dimethylacetamide is considered to be a hazardous chemical that can cause irritation to the skin, eyes, and respiratory system. It is important to handle and use this chemical with caution and in accordance with proper safety guidelines.

InChI:InChI=1/C4H7Cl2NO/c1-7(2)4(8)3(5)6/h3H,1-2H3

Upstream product

• 51-80-9 bis-(dimethylamino)methane 
• 4124-30-5 dichloroacetic anhydride 
• 79-36-7 dichloroacethyl chloride 
• 116422-06-1 2,2-Dichloro-N,N-dimethyl-2-trimethylsilanyl-acetamide 
• 684-98-0 1,1,2-Trichloro-2-(dimethylamino)ethen 
• 124-40-3 dimethyl amine 

Downstream Products

• 25408-61-1 Ν,Ν-dimethylacetamide dimethyl acetal 
• 32803-76-2 N,N-dimethylamide of 3-phenyl-3-chloro-2-ketopropionic acid 

Relevant articles and documents

Preparation method of zolpidem

The invention discloses a preparation method of a zolpidem intermediate. In the process of preparing the zolpidem intermediate N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride by reducing N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride, through process optimization and parameter adjustment, by using a 10% palladium-carbon catalyst and combining the reaction condition of hydrogen pressure of 0.02-0.09 MPa, the conversion effect of the N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-chloroacetamide hydrochloride is promoted, side reactions and impurities are reduced, the product yield is increased, the problem of low product synthesis yield in the process of preparing N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride through reduction reaction in zolpidem production is solved, and the production cost of zolpidem tartrate is reduced.

Enantioselective Oxidation of Thioethers: Synthesis of trans-2-N,N-Dialkylacetamide-1,3-dithiolanes-S-oxide and Their Use in Asymmetric Aldol-Type Reactions

(-)-trans-2-N,N-dialkylacetamide-1,3-dithiolanes-S-oxide 2 have been obtained in high d.e. (>99:1) and e.e.(up to 94percent, >98percent after crystallization) by enantioselective oxidation .The aldol-type addition of the magnesium enolate of the N,N-diethyl derivative (-)-2b to iso-butyraldehyde afforded good chemical yields of a single diastereomer.Key Words: Enantioselective oxidation; Asymmetric aldol-type addition, trans-(-)-2-N,N-Diethylacetamide-1,3-dithiolane-S-oxide.

SILYLATION OF COMPOUNDS CONTAINING TRICHLOROMETHYL GROUPS

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