5468-76-8

Usage

Uses

Used in Pharmaceutical Industry:
2,2-dichloro-N,N-dimethylacetamide is used as a solvent for the production of pharmaceuticals, facilitating the manufacturing process by dissolving various substances that are otherwise difficult to process.
Used in Pesticide Production:
In the agricultural sector, 2,2-dichloro-N,N-dimethylacetamide serves as a solvent in the production of pesticides, aiding in the formulation and application of these chemicals to enhance crop protection.
Used in Dye Manufacturing:
2,2-dichloro-N,N-dimethylacetamide is also utilized as a solvent in the dye industry, where it helps in the creation of various dyes used in textiles and other applications.
Used in Organic Synthesis:
2,2-dichloro-N,N-dimethylacetamide is employed as a reagent in organic synthesis, contributing to the development of new chemical compounds and materials.
Used as a Paint Remover:
Beyond its industrial applications, this chemical compound is also used as a paint remover, effectively stripping paint from surfaces in preparation for repainting or other treatments.
It is crucial to acknowledge that 2,2-dichloro-N,N-dimethylacetamide is a hazardous chemical, posing risks of irritation to the skin, eyes, and respiratory system. Therefore, it must be handled and used with caution, adhering to stringent safety guidelines to mitigate potential health and environmental hazards.

InChI:InChI=1/C4H7Cl2NO/c1-7(2)4(8)3(5)6/h3H,1-2H3

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 124-40-3 dimethyl amine 
• 116422-06-1 2,2-Dichloro-N,N-dimethyl-2-trimethylsilanyl-acetamide 
• 51-80-9 bis-(dimethylamino)methane 
• 4124-30-5 dichloroacetic anhydride 
• 684-98-0 1,1,2-Trichloro-2-(dimethylamino)ethen 

Downstream Products

• 25408-61-1 Ν,Ν-dimethylacetamide dimethyl acetal 
• 32803-76-2 N,N-dimethylamide of 3-phenyl-3-chloro-2-ketopropionic acid 

Relevant academic research and scientific papers

Preparation method of zolpidem

The invention discloses a preparation method of a zolpidem intermediate. In the process of preparing the zolpidem intermediate N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride by reducing N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride, through process optimization and parameter adjustment, by using a 10% palladium-carbon catalyst and combining the reaction condition of hydrogen pressure of 0.02-0.09 MPa, the conversion effect of the N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-chloroacetamide hydrochloride is promoted, side reactions and impurities are reduced, the product yield is increased, the problem of low product synthesis yield in the process of preparing N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride through reduction reaction in zolpidem production is solved, and the production cost of zolpidem tartrate is reduced.

PROCESS FOR THE PREPARATION OF 4,4-DIFLUORO-3-OXOBUTANOIC ACID ESTERS

The present invention relates to a process for the preparation of a compound of the formula (I), wherein R is C1-12 alkyl, by the contact of a compound of the general formula (II) , wherein R1 and R2 are each, independently, C1-12 alkyl; or R1 and R2 join together with the nitrogen atom to which they are attached to form an alicyclic amine ring containing 4 to 7 carbon atoms or a morpholine ring, with an acetic acid ester of the general formula (III) CH3COOR, wherein R is as defined under formula (I), in the presence of a base.

Enantioselective Oxidation of Thioethers: Synthesis of trans-2-N,N-Dialkylacetamide-1,3-dithiolanes-S-oxide and Their Use in Asymmetric Aldol-Type Reactions

(-)-trans-2-N,N-dialkylacetamide-1,3-dithiolanes-S-oxide 2 have been obtained in high d.e. (>99:1) and e.e.(up to 94percent, >98percent after crystallization) by enantioselective oxidation .The aldol-type addition of the magnesium enolate of the N,N-diethyl derivative (-)-2b to iso-butyraldehyde afforded good chemical yields of a single diastereomer.Key Words: Enantioselective oxidation; Asymmetric aldol-type addition, trans-(-)-2-N,N-Diethylacetamide-1,3-dithiolane-S-oxide.

Process for the preparation of imidazopyridines

A process for the preparation of an imidazopyridine which is a compound of formula (I) STR1 in which: Y denotes hydrogen, a halogen or a C1-4 alkyl group; X1 and X2 denote, independently of each other, hydrogen, a halogen or a C1-4 alkoxy, C1-6 alkyl, CF3, CH3 S, CH3 SO2 or NO2 group; and R1 and R2 denote, independently of each other, hydrogen or a C1-5 alkyl group, with the proviso that R1 and R2 do not both denote hydrogen, or a salt thereof; which process comprises reacting a compound of formula (V) STR2 wherein Y, X1, X2, R1 and R2 are as defined above, with a reducing agent and if desired converting the resulting compound of formula (I) into a salt, together with intermediates of formulae: STR3 The final products have useful pharmacological properties, e.g. as anxiolytics.