5469-51-2

Basic information

• Product Name: 2-(2-methylbenzoyl)benzoic acid
• Synonyms: 2-(2-methylphenyl)carbonylbenzoic acid
• CAS NO: 5469-51-2
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.253980
• Mol File: 5469-51-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 419.1 °C at 760 mmHg
• Flash Point: 221.4 °C
• Appearance: /
• Density: 1.223 g/cm³
• Vapor Pressure: 8.97E-08mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 2-(2-methylbenzoyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methylbenzoyl)benzoic acid(5469-51-2)
• EPA Substance Registry System: 2-(2-methylbenzoyl)benzoic acid(5469-51-2)

Safety Data

• Hazardous Substances Data: 5469-51-2(Hazardous Substances Data)

Usage

Structure

A benzoyl group attached to the second carbon of a methylbenzene ring, which is a derivative of benzoic acid

Usage

Building block in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals

Biological activities

Potential anti-inflammatory and anti-tumor properties

Applications in materials science and environmental analysis

Due to its distinctive chemical and physical properties

InChI:InChI=1/C15H12O3/c1-10-6-2-3-7-11(10)14(16)12-8-4-5-9-13(12)15(17)18/h2-9H,1H3,(H,17,18)

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 85-44-9 phthalic anhydride 
• 71-43-2 benzene 
• 65-85-0 benzoic acid 
• 7664-93-9 sulfuric acid 
• 95-50-1 1,2-dichloro-benzene 
• 1018-97-9 2,2'-dimethylbenzophenone 

Downstream Products

• 21147-26-2 2-(2-methylbenzoyl)benzoic acid methyl ester 
• 137537-30-5 2-Isopropyl-1-oxo-4-o-tolyl-1,2-dihydro-isoquinoline-3-carbonitrile 
• 137537-43-0 N-Cyanomethyl-N-isopropyl-2-(2-methyl-benzoyl)-benzamide 
• 137537-54-3 2-Isopropyl-1-oxo-4-o-tolyl-1,2-dihydro-isoquinoline-3-carboxylic acid amide 
• 1227504-96-2 (S)-3-(2-methylphenyl)isobenzofuran-1(3H)-one 
• 90445-44-6 3-(2-methylphenyl)isobenzofuran-1(3H)one 
• 80716-39-8 N,N-diethyl-2-(2-methylbenzyl)benzamide 
• 152818-52-5 1,2-dihydro-2-methyl-4-(2-methylphenyl)-1-oxo-3-isoquinolinecarboxylic acid 
• 170639-95-9 1,2-dihydro-2-methyl-4-(2-methylphenyl)-1-oxo-3-isoquinolinecarboxamide 
• 159817-05-7 N-[3,5-Bis(trifluoromethyl)benzyl]-1,2-dihydro-2-methyl-4-(2-methylphenyl)-1-oxo-3-isoquinolinecarboxamide 
• 159817-18-2 1,2-Dihydro-N-(2-methoxybenzyl)-2-methyl-4-(2-methylphenyl)-1-oxo-3-isoquinolinecarboxamide 
• 1026397-73-8 2-Methyl-1-oxo-4-o-tolyl-1,2-dihydro-isoquinoline-3-carbonyl chloride 
• 170639-94-8 1,2-dihydro-2-methyl-4-(2-methylphenyl)-1-oxo-3-isoquinolinecarbonitrile 
• 170639-93-7 N-(cyanomethyl)-N-methyl-2-(2-methylbenzoyl)benzamide 

Relevant articles and documents

Construction of an isoquinolinone framework from carboxylic-ester-directed umpolung ring opening of methylenecyclopropanes

An interesting type of reaction involving functionalized methylenecyclopropanes (MCPs) has been revealed. Here, a nucleophilic attack of an anionic species onto a partially polarity-reversed MCP was realized by treating a neighbouring carboxylic ester tethered to the MCP and amine with KHMDS to realize an umpolung ring opening of the MCP. This work established an operationally convenient protocol for the rapid construction of isoquinolinone frameworks. This journal is

Palladium-catalyzed chemoselective decarboxylative ortho acylation of benzoic acids with α-oxocarboxylic acids

Palladium-catalyzed chemoselective decarboxylative cross coupling of benzoic acids with α-oxocarboxylic acids was realized via an arene sp 2 C-H functionalization process. This work represents the first example of transition-metal-catalyzed cro

Process for preparing 2-(alkylbenzoyl)benzoic acid

An environmentally acceptable process is provided to synthesize a 2-(alkylbenzoyl)benzoic acid suitable for synthesizing a 2-alkylanthraquinone without further purification. Usually the crude product is isolated from the reaction mixture by a succession of steps which generate a large volume of aqueous waste. The present process eliminates or decreases these wastes and produces a product of sufficient purity for synthesizing as 2-alkylanthraquinone.