54712-18-4

Basic information

• Product Name: 2-Octanol, acetate, (R)-
• CAS NO: 54712-18-4
• Molecular Formula: C10H20O2
• Molecular Weight: 172.268
• Mol File: 54712-18-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2-Octanol, acetate, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Octanol, acetate, (R)-(54712-18-4)
• EPA Substance Registry System: 2-Octanol, acetate, (R)-(54712-18-4)

Safety Data

• Hazardous Substances Data: 54712-18-4(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 4128-31-8 rac-octan-2-ol 
• 32786-26-8 1-phenylethyl 2-methoxyacetate 
• 629-05-0 n-octyne 
• 64-19-7 acetic acid 
• 85-44-9 phthalic anhydride 
• 108-22-5 Isopropenyl acetate 
• 26735-84-2 oct-1-en-2-yl acetate 

Downstream Products

• 106760-31-0 (R)(-)-N,N'-dicyclohexyl-O-(1-methylheptyl)-isourea 
• 135628-86-3 (S)-(+)-2-(1-Methylheptyl)phenol 
• 103481-63-6 (S)-(+)-4-(1-Methylheptyl)phenol 
• 54739-11-6 (S)-(+)-(1-Methylheptyl) phenyl ether 
• 5978-70-1 (R)-Octan-2-ol 

Relevant articles and documents

CO2-expanded bio-based liquids as novel solvents for enantioselective biocatalysis

For the first time, CO2-expanded bio-based liquids were reported as novel and sustainable solvents for biocatalysis. Herein, it was found that by expansion with CO2, 2-methyltetrahydrofuran (MeTHF), and other bio-based liquids, which were not favorable solvents for immobilized Candida antarctica lipase B (Novozym 435) catalyzed transesterification, were tuned into excellent reaction media. Especially, for the kinetic resolution of challenging bulky secondary substrates such as rac-1-adamantylethanol, the lipase displayed very high activity with excellent enantioselectivity (E value > 200) in CO2-expanded MeTHF (MeTHF concentration 10% v/v, 6 MPa), whereas there was almost no activity observed in conventional organic solvents.

Dynamic double kinetic resolution of amines and alcohols under the cocatalysis of Raney nickel/Candida antarctica lipase B: From concept to application

Herein, we have established a dynamic double kinetic resolution (DDKR) strategy under the co-catalysis of Raney nickel and Candida antarctica lipase B (CAL-B) for the one-pot simultaneous resolution of primary amines and secondary alcohols (or esters). The DDKR strategy was successfully applied to the resolution of a series of racemic amines and secondary alcohols (or esters) as well as mexiletine, an important antiarrhythmic agent. The catalysts could be recycled and reused several times with the same high activity. Scale-up experiments were also successful. As a more atom-economical and efficient process than traditional simple kinetic resolutions, the DDKR strategy can be widely used to prepare optically pure amines and alcohols.

Highly enantioselective Rh-catalysed hydrogenation of 1-alkyl vinyl esters using phosphine-phosphoramidite ligands

MatPhos, a good mate for hard tasks: The asymmetric hydrogenation of 1-alkyl vinyl esters, thwarted so far by mediocre ee values and low activities, can now be achieved with MatPhos/Rh catalysts with ee values of 96-99 % for a variety of substrates at low catalyst loadings (0.1-1 mol %) and under mild conditions (5-20 bar H2, room temperature). After hydrolysis, the corresponding chiral secondary alkyl alcohols can be obtained in high enantiopurities providing a general and practical route to this important product class. Copyright