54714-49-7

Usage

Uses

Used in Pharmaceutical Industry:
DIISOPROPYLAMINOACETONITRILE is used as a reagent for the synthesis of various pharmaceuticals, leveraging its strong base and nucleophilic properties to facilitate the creation of diverse medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, DIISOPROPYLAMINOACETONITRILE is utilized as a reagent in the preparation of a range of agrochemicals, contributing to the development of products designed to enhance crop protection and yield.
Used in Organic Synthesis:
DIISOPROPYLAMINOACETONITRILE is employed as a key reagent in organic synthesis processes, where its ability to act as a strong base and nucleophile is instrumental in the formation of a wide array of chemical products.

InChI:InChI=1/C8H16N2/c1-7(2)10(6-5-9)8(3)4/h7-8H,6H2,1-4H3

Upstream product

• 10342-97-9 N,N-diisopropylmethylamine 
• 143-33-9 sodium cyanide 
• 50-00-0 formaldehyd 
• 151-50-8 potassium cyanide 
• 108-18-9 diisopropylamine 
• 590-17-0 cyanomethyl bromide 
• 107-14-2 chloroacetonitrile 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 406913-26-6 N,N-diisopropyl-2-cyanothioacetamide 
• 121-05-1 N',N'-diisopropyl-ethane-1,2-diamine 

Relevant academic research and scientific papers

Synthesizing method of N,N-diisoprylamino ethylamine

The invention discloses a synthesizing method of N,N-diisoprylamino ethylamine. The synthesizing method comprises the following steps of using diisopropylamine and chloroacetonitrile as initial raw materials, and performing aminolysis reaction and reduction reaction, so as to synthesize the N,N-diisoprylamino ethylamine. The synthesizing method has the advantages that the technology route is advanced, the technology condition is reasonable, the cost of raw materials is low, the obtaining is easy, the reaction condition is mild, the operation is simple and safe, the atom economy is high, the production cost is low, the amount of three wastes (waste gas, waste water and industrial residue) is small, the synthesizing method is suitable for industrialized production, and the larger implementing value and social and economical benefits are realized.

Visible-light-induced photoredox catalysis with a tetracerium-containing silicotungstate

The development of visible-light-induced photocatalysts for chemoselective functional group transformations has received considerable attention. Polyoxometalates (POMs) are potential materials for efficient photocatalysts because their properties can be p

An oxazaphospholidine approach for the stereocontrolled synthesis of oligonucleoside phosphorothioates

The stereocontrolled synthesis of oligodeoxyribonucleoside phosphorothioates (PS-ODNs) using nucleoside 3′-O-oxazaphospholidine derivatives as monomer units is described. 2-Chloro-1,3,2-oxazaphospholidine derivatives were prepared from six kinds of enantiopure 1,2-amino alcohols and used for the phosphitylation reactions of 5′-O-protected nucleosides. A detailed study of these reactions revealed that the diastereoselectivity of the reaction depended on the structure of the enantiopure 1,2-amino alcohol, the reaction temperature, and the amine used as a scavenger of HCI. In addition, ab initio molecular orbital calculations for the 2-chlorooxazaphospholidine derivatives were carried out to elucidate the mechanism of these diastereoselective phosphitylation reactions. The LUMO of the 2-chloro-5-phenyloxazaphospholidine derivatives on the phosphorus atom was found to be almost orthogonal to the P-CI bond. This LUMO may be involved in the phosphitylation reactions with predominant retention of the P-configuration. A series of dialkyl(cyanomethyl)ammonium salts were developed and used as activators for the condensation reactions of the diastereopure nucleoside 3′-O-oxazaphospholidines with 3′-O-protected nucleosides. In the presence of the new activators, the reactions proceeded rapidly to give the corresponding dinucleoside phosphite triesters. The diastereoselectivity of the condensation reaction did not depend on the counteranion but on the structure of the dialkyl(cyanomethyl)amine. In the presence of the activator, which consists of a relatively small dialkyl(cyanomethyl)amine, the condensation proceeded with excellent diastereoselectivity. After sulfurization and deprotection, diastereopure (Rp)- and (Sp)-dinucleoside phosphorothioates were obtained in excellent yields. The present methodology was also applied to the solid-phase synthesis of stereoregulated PS-ODNs. all-(Rp)-[TPS]3T, all-(Sp)-[TPS]3T, all-(Rp)-d[GPSAPSCPS]T, and all-(Rp)-[TPS]9T were synthesized on a highly cross-linked polystyrene resin.

C-C - CONNECTIVE SYNTHESIS OF α-DIALKYLAMINO - KETONES FROM ALDEHYDES AND SEC.-AMINES

A simple and efficient 3 - step synthesis of α-dialkylamino - ketones 3 starting from aldehydes and sec.-amines is described.The unsymmetrically aminoketones are obtained as pure regioisomers via reaction of metalated α-aminonitriles 1 with aldehydes, followed by thermal HCN-elimination/tautomerization.