5472-37-7

Basic information

• Product Name: N-(2-AMINO-4-METHOXYPHENYL)ACETAMIDE
• Synonyms: 2-AMINO-4-METHOXYACETANILIDE;3-AMINO-4-ACETAMIDOANISOLE;4-ACETAMINO-3-AMINOANISOLE;N1-(2-AMINO-4-METHOXYPHENYL)ACETAMIDE;N-(2-AMINO-4-METHOXYPHENYL)ACETAMIDE;N-(2-amino-4-methoxyphenyl)acetamide(SALTDATA: FREE);N-(2-Amino-4-methoxyphenyl)acetamide, 2-Acetamido-5-methoxyaniline
• CAS NO: 5472-37-7
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 180.2
• Product Categories: Intermediates of Dyes and Pigments;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 5472-37-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 150-153°C
• Boiling Point: 403°Cat760mmHg
• Flash Point: 197.5°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 1.05E-06mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: N-(2-AMINO-4-METHOXYPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMINO-4-METHOXYPHENYL)ACETAMIDE(5472-37-7)
• EPA Substance Registry System: N-(2-AMINO-4-METHOXYPHENYL)ACETAMIDE(5472-37-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 5472-37-7(Hazardous Substances Data)

Usage

General Description

N-(2-amino-4-methoxyphenyl)acetamide, also known as 4-Acetamidoguaiacol, is a chemical compound with the molecular formula C9H12N2O2. It is a white to off-white crystalline powder that is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. N-(2-AMINO-4-METHOXYPHENYL)ACETAMIDE is also known for its analgesic and anti-inflammatory properties, and it has been studied for its potential use in the treatment of various diseases and conditions. Additionally, N-(2-amino-4-methoxyphenyl)acetamide has been investigated for its potential role in the development of new therapeutic agents. However, it is important to handle this compound with care and follow proper safety protocols when working with it in a laboratory setting.

InChI:InChI=1/C9H12N2O2/c1-6(12)11-9-4-3-7(13-2)5-8(9)10/h3-5H,10H2,1-2H3,(H,11,12)

Upstream product

• 119-81-3 4-methoxy-2-nitroacetanilide 
• 64-19-7 acetic acid 

Downstream Products

• 67169-65-7 C₁₄H₁₈N₄O₆ 
• 113001-06-2 N-(4-Methoxy-2-{[1-(2-nitro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-acetamide 
• 158531-08-9 N-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methoxy-phenyl]-acetamide 
• 1514589-89-9 N-(4-methoxy-2-{[(5-methylfuran-2-yl)methylidene]amino}phenyl)acetamide 
• 1514590-15-8 C₂₂H₂₃N₃O₂ 
• 1514589-94-6 C₁₅H₁₈N₂O₃ 
• 37052-78-1 2-Mercapto-5-methoxybenzimidazole 
• 100128-36-7 N,N'-(4-methoxy-5-nitro-o-phenylene)-bis-acetamide 
• 100394-60-3 4-methoxy-2-phenylazo-aniline 
• 27799-91-3 5-methoxy-1H-benzo[d][1,2,3]triazole 
• 37052-78-1 6-methoxy-1H-benzoimidazole-2-thiol 
• 79938-46-8 1-acetyl-5-methoxybenzimidazole 
• 158531-01-2 2-(2-Amino-5-methoxy-phenyl)-isoindole-1,3-dione 
• 100537-54-0 N-(2-amino-5-hydroxy-phenyl)-phthalimide 

Relevant articles and documents

Synthesis of 2-methyl-1-[(5-methylfuran-2-yl)methyl]- and 2-methyl-1-[(5-methylpyrrol-2-yl)methyl]-1H-benzimidazoles

A method for the synthesis of 2-methyl-1-[(5-methylfuran-2-yl)methyl]-1H- benzimidazoles based on the intramolecular cyclization of vicinal N-[(5-methylfuran-2-yl)methyl]aminoanilides has been developed. A study was carried out on the protolytic opening o

Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin

The synthesis and pharmacological activity of isoindolo[1,2-b]quinazolin- 12(10H)-ones and isoindolo[2,1-a]benzimidazoles related to batracylin are described. The acute toxicity of batracyclin has been associated with the formation of its N-acetyl metabolite which is a potent inducer of unscheduled DNA synthesis in rat hepatocytes. The desamino derivative and the 8-aza analog of batracylin retained the ability to inhibit topoisomerase II but did not induce unscheduled DNA synthesis. While less active than batracylin, these analogs were cytotoxic to CCRF CEM leukemia cells. The isoindolo[2,1- a]benzimidazole derivatives were inactive as topoisomerase II inhibitors and, in general, failed to exhibit comparable antitumor activity or to induce unscheduled DNA synthesis.

Synthesis of N-Acetylbenzimidazole Derivatives

For the structure determination of thiazolobenzimidazol-3(2H)-one derivatives (2 or 3) they were converted to the corresponding 1-acetylbenzimidazoles (4) by desulfurization.The latter compounds (4) were alternatively prepared by the cyclization of 2-aminoacetanilide derivatives (5) with CS2 in dimethylformamide (DMF), followed by desulfurization with Raney Ni.However, the reactions of 5 with ethyl orthoformate/H2SO4 in DMF gave a mixture of 4 and its acetyl-rearranged product (7).Keywords-acetyl group; rearrangement; thiazolobenzimidazol-3(2H)-one; N-acetylbenzimidazoles; ethyl orthoformate; carbon disulfide; desulfurization