54734-84-8

Basic information

• Product Name: 2-AMINO-5-BROMOBENZENESULPHONAMIDE
• Synonyms: 2-AMINO-5-BROMOBENZENESULPHONAMIDE;4-Bromo-2-sulphamoylaniline;4-Bromo-2-sulphamoylaniline, 2-(Aminosulphonyl)-4-bromoaniline
• CAS NO: 54734-84-8
• Molecular Formula: C₆H₇BrN₂O₂S
• Molecular Weight: 251.10098
• Mol File: 54734-84-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 170-176°C
• Boiling Point: 424.4°C at 760 mmHg
• Flash Point: 210.5°C
• Appearance: /
• Density: 1.834g/cm³
• Vapor Pressure: 2.07E-07mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-AMINO-5-BROMOBENZENESULPHONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-BROMOBENZENESULPHONAMIDE(54734-84-8)
• EPA Substance Registry System: 2-AMINO-5-BROMOBENZENESULPHONAMIDE(54734-84-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 54734-84-8(Hazardous Substances Data)

Usage

General Description

2-Amino-5-bromobenzenesulfonamide is a chemical compound with the molecular formula C6H6BrNO2S. It is an important intermediate in the synthesis of pharmaceuticals and dyes. 2-AMINO-5-BROMOBENZENESULPHONAMIDE is an aromatic amine and contains a sulfonamide group, which makes it useful in various organic reactions and drug formulations. 2-Amino-5-bromobenzenesulfonamide is an important building block for the synthesis of pharmaceuticals, particularly in the development of anti-inflammatory and antiviral drugs. It is also used in the production of dyes and pigments. 2-AMINO-5-BROMOBENZENESULPHONAMIDE is known for its high stability and solubility in water, making it a versatile and valuable compound in the chemical and pharmaceutical industries.

InChI:InChI=1/C6H7BrN2O2S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3H,8H2,(H2,9,10,11)

Upstream product

• 89599-01-9 3-bromobenzenesulfonamide 
• 321-23-3 4-bromo-2-fluoronitrobenzene 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 5455-59-4 2-Nitrobenzenesulfonamide 
• 106-40-1 4-bromo-aniline 
• 14141-71-0 7-bromo-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 

Downstream Products

• 14141-71-0 7-bromo-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide 
• 37162-46-2 7-bromo-4H-1,2,4-benzothiadiazine 1,1-dioxide 
• 686265-42-9 N-[2-(aminosulfonyl)-4-bromophenyl]-1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide 
• 686266-22-8 N-[2-(aminosulfonyl)phenyl]-1-(benzyloxy)-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide 
• 686267-53-8 N-[2-(aminosulfonyl)phenyl]-4-hydroxy-1-isobutoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide 
• 690959-90-1 N-[2-(aminosulfonyl)phenyl]-4-hydroxy-2-oxo-1-propoxy-1,2-dihydroquinoline-3-carboxamide 
• 1560648-26-1 C₁₉H₁₈BrN₃O₄S 
• 40018-42-6 7-bromo-3-phenyl-2H-benzo[1,2,4]thiadiazine 1,1-dioxide 

Relevant articles and documents

Iridium-Catalyzed ortho-C?H Amidation of Benzenesulfonamides with Sulfonyl Azides

We developed herein an iridium-catalyzed direct C?H activation/ C?N bond formation reaction of benzenesulfonamides with sulfonyl azides. The amidation reaction provides a protocol for the synthesis of 2-aminobenzesulfonamides in good to excellent yields. This strategy features a wide substrate scope, tolerates a broad range of functional groups under external oxidant-free conditions and only releases molecular nitrogen as the sole by-product. Moreover, the preliminary mechanism was investigated and the proposed reaction pathway was provided. (Figure presented.).

1. 1 - dioxo - 4H - benzo [1, 2, 4] - thiadiazine hydrochloric acid salt compound and its preparation method

The invention discloses a 1,1-dioxo-4H-benzo[1,2,4]-thiadiazine hydrochloride compound and a preparation method thereof, belonging to the technical field of organic synthesis. The technical scheme has the key point as follows: the 1,1-dioxo-4H-benzo[1,2,4]- thiadiazine hydrochloride compound has the structure as shown in the specification, wherein R is H, -CH3 or -C2H5. The invention also discloses the preparation method of the 1,1-dioxo-4H-benzo[1,2,4]-thiadiazine hydrochloride compound. The preparation method is simple, convenient and easy to operate, relatively high in reaction efficiency and relatively good in repeatability, and raw materials are cheap and available.

Erratum: Integrated structure-based activity prediction model of benzothiadiazines on various genotypes of HCV NS5b polymerase (1a, 1b and 4) and its application in the discovery of new derivatives (Bioorganic and Medicinal Chemistry (2012) 20:7 (2455-2478))

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