54778-23-3

Upstream product

• 28284-05-1 N-benzoylisatin 
• 91-56-5 indole-2,3-dione 
• 98-88-4 benzoyl chloride 
• 72738-57-9 trans-N,N'-dibenzoylindigo 
• 7647-01-0 hydrogenchloride 
• 93-97-0 benzoic acid anhydride 
• 31588-18-8 3-hydroxy-2-phenyl-1H-quinolin-4-one 
• 64-17-5 ethanol 

Downstream Products

• 854674-59-2 (2-benzoylamino-phenyl)-glyoxylic acid ethyl ester 
• 28284-05-1 N-benzoylisatin 
• 7672-01-7 2-phenylquinazoline-4-carboxylic acid 
• 33768-43-3 N-(2-formylphenyl)benzamide 
• 1791-58-8 5-phenyl-2,3-dihydro-thiazolo[3,2-c]quinazoline-3,10b-dicarboxylic acid 
• 1791-59-9 5-phenyl-2,3-dihydro-thiazolo[3,2-c]quinazoline-3,10b-dicarboxylic acid 3-ethyl ester 
• 1791-57-7 5-phenyl-2,3-dihydro-thiazolo[3,2-c]quinazoline-10b-carboxylic acid 
• 85080-47-3 (2-benzoylamino-phenyl)-glyoxylic acid amide 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 

Relevant academic research and scientific papers

Silver-Mediated Synthesis of 4H-Benzoxazin-4-ones by Intramolecular Decarboxylative O-Acylation Reactions with α-Oxocarboxylic Acid

The first example of an intramolecular decarboxylative acylation reaction for the synthesis of 4H-benzoxazin-4-one derivatives has been described. The silver-mediated reaction has a broad substrate scope and provides a mild and rapid approach to the corre

Kinetics and mechanism of the base-catalyzed oxygenation of 1H-2-phenyl-3-hydroxy-4-oxoquinolines in DMSO/H2O

The oxygenation of 4′-substituted 1H-2-phenyl-3-hydroxy-4- oxoquinolines (PhquinH2) in a DMSO/H2O (50/50) solution leads to the cleavage products at the C2-C3 bond in about 75% yield at room temperature. The oxygenation, deduced from the product compositions, has two main pathways, one proceeding via an endoperoxide leading to CO-release, and the other through a 1,2-dioxetane intermediate without CO-loss. The reaction is specific base-catalyzed and the kinetic measurements resulted in the rate law -a...?[PhquinH2]/a...?t=kOH - [OH-] [PhquinH2] [O2]. The rate constant, activation enthalpy, and entropy at 303.16 K are as follows: kOH-=(2.42±0.03)×103mol -2L2s-1; ΔG?=73. 13±4.02 kJ mol-1; ΔH?=70.60±4. 04 kJ mol-1; ΔS?=-28±2 J mol -1 K-1. The reaction fits a Hammett linear free energy relationship for 4′-substituted substrates, and electron-releasing groups make the oxygenation reaction faster (ρ=-0.258). The EPR spectrum of the reaction mixtures showed the presence of the organic radical 1H-2-phenyl-3-oxyl-4-oxoquinoline and superoxide ion due to single electron transfer from the carbanion to dioxygen. The pathway via 1,2-dioxetane could be proved by chemiluminescence measurements.